Antidepressant medication and ocular factors in association with the need for anti-VEGF retreatment in neovascular age-related macular degeneration.

Details

Serval ID
serval:BIB_A0255087CC94
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antidepressant medication and ocular factors in association with the need for anti-VEGF retreatment in neovascular age-related macular degeneration.
Journal
The British journal of ophthalmology
Author(s)
Mantel I., Zola M., Mir O., Gaillard R., Behar-Cohen F.
ISSN
1468-2079 (Electronic)
ISSN-L
0007-1161
Publication state
Published
Issued date
06/2019
Peer-reviewed
Oui
Volume
103
Number
6
Pages
811-815
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Observational Study
Publication Status: ppublish
Abstract
Vascular endothelial growth factor (VEGF) is a key player in the pathogenesis of neovascular age-related macular degeneration (nAMD) and is also involved in the final common pathway of antidepressant medication. This study investigated the relationship between the need for anti-VEGF retreatment in patients with nAMD and antidepressant medication, and the potential impact of ocular structural factors.
Data from two identical prospective 2-year treatment protocols using ranibizumab or aflibercept in a variable-dosing regimen ('Observe-and-Plan') were analysed. Retreatment requirement was compared with antidepressant medication intake (primary outcome) and a variety of ocular factors from baseline and from month 3 response (secondary outcomes), using univariate and multivariate analyses.
Of the 206 included patients (227 eyes), 19 were on antidepressant medication. Their nAMD eyes significantly more often had pigment epithelium detachment (PED, p=0.04). Multivariate analysis revealed a significant association between anti-VEGF retreatment requirement and antidepressant medication use (p=0.027), as well as thicker central retinal thickness at month 3 (p<0.0001) and month 3 PED height (p=0.001).
This study provides evidence that treatment with antidepressant medication increases the anti-VEGF retreatment requirement in patients with nAMD, possibly through the interplay of antidepressant medication, depression status and VEGF levels.
Keywords
Aged, Angiogenesis Inhibitors/administration & dosage, Antidepressive Agents/therapeutic use, Depression/complications, Depression/diagnostic imaging, Drug Therapy, Combination, Female, Fluorescein Angiography, Follow-Up Studies, Fundus Oculi, Humans, Intravitreal Injections, Male, Prospective Studies, Ranibizumab/administration & dosage, Receptors, Vascular Endothelial Growth Factor/administration & dosage, Recombinant Fusion Proteins/administration & dosage, Retina/diagnostic imaging, Retreatment/methods, Time Factors, Tomography, Optical Coherence, Treatment Outcome, Vascular Endothelial Growth Factor A/antagonists & inhibitors, Wet Macular Degeneration/complications, Wet Macular Degeneration/diagnosis, Wet Macular Degeneration/drug therapy, angiogenesis, degeneration, drugs, medical treatment, retina
Pubmed
Web of science
Open Access
Yes
Create date
31/07/2018 11:33
Last modification date
12/02/2020 7:19
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