Vascular endothelial function in cyclosporine and tacrolimus treated renal transplant recipients
Details
Serval ID
serval:BIB_9FF57521C3F7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vascular endothelial function in cyclosporine and tacrolimus treated renal transplant recipients
Journal
Transplantation
ISSN
0041-1337
Publication state
Published
Issued date
10/2001
Peer-reviewed
Oui
Volume
72
Number
8
Pages
1385-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct 27
Research Support, Non-U.S. Gov't --- Old month value: Oct 27
Abstract
BACKGROUND: Endothelial dysfunction is an early key event in the development of arteriosclerotic cardiovascular disease (ASCVD), thus an early marker of subclinical ASCVD. Endothelial function is impaired in renal transplant recipients (RTR) treated with cyclosporine (CyA). Tacrolimus is associated with less hyperlipidemia and hypertension than CyA, however, there are no data on endothelial function in tacrolimus-treated RTR. METHODS: High-resolution brachial ultrasonography was used to assess endothelium-dependent dilatation (EDD), and endothelium-independent dilatation (EID) in 20 stable RTR and a control group of 10 healthy subjects without clinical evidence of ASCVD. The RTR group included patients receiving CyA (n=10) and tacrolimus (n=10). EDD and EID were measured as percent increase in brachial artery diameter in response to reactive hyperemia and nitroglycerin, respectively. RESULTS AND CONCLUSIONS: EDD was significantly lower in RTR versus controls (1.7+/-0.7 vs. 7.3+/-0.7%, P<0.0001), whereas EID was similar in the two groups. No significant differences were found in EDD or in EID between CyA- and tacrolimus-treated RTR. Glomerular filtration rate, plasma homocysteine, blood pressure, and lipid profiles were similar in CyA- and tacrolimus-treated RTR.
Keywords
Adult
Arteriosclerosis/etiology
Cyclosporine/*adverse effects
Endothelium, Vascular/*drug effects/physiology
Female
Humans
Immunosuppressive Agents/*adverse effects
Kidney Transplantation/*adverse effects
Male
Risk Factors
Tacrolimus/*adverse effects
Vasodilation
Pubmed
Web of science
Create date
29/01/2008 14:53
Last modification date
20/08/2019 16:06