[Pseudomonas aeruginosa and Surfactant-associated Proteins A and D]

Details

Serval ID
serval:BIB_9FCF61491D5F
Type
Article: article from journal or magazin.
Collection
Publications
Title
[Pseudomonas aeruginosa and Surfactant-associated Proteins A and D]
Journal
Med Mal Infect
Author(s)
Faure K., Leberre R., Guery B.
ISSN
0399-077X (Print)
ISSN-L
0399-077X
Publication state
Published
Issued date
02/2006
Volume
36
Number
2
Pages
63-71
Language
english
Notes
Faure, K
Leberre, R
Guery, B
fre
France
Med Mal Infect. 2006 Feb;36(2):63-71. doi: 10.1016/j.medmal.2005.08.011. Epub 2006 Jan 5.
Abstract
Surfactant-associated proteins A and D (SP-A and SP-D) are two pulmonary collectins that bind to bacterial, fungal and viral pathogens and have multiples classes of receptors on pneumocyte and macrophage membrane. They are chemoattractant for phagocytes, enhance uptake and killing of bacteria by macrophages and neutrophils. These molecules also act as activation ligand on macrophages and neutrophils to enhance phagocytosis, resulting in an increased bacterial clearance. Depending on activation of cells by stimuli, SP-A and SP-D modulate production of antimicrobial free radicals by phagocytes and secretion of cytokines. In vivo, SP-A deficient mice infected with Pseudomonas aeruginosa (P. aeruginosa) have decreased bacterial clearance and exacerbated inflammatory response in the lungs. Serious alterations in macrophages and increased production of reactive oxygen species were found in non-infected SP-D deficient mice. Patients with cystic fibrosis are frequently colonized by P. aeruginosa. Decreased levels of SP-A and SP-D have been measured in bronchoalveolar lavage fluid of these patients, as well as patients with acute pneumonia but no chronic lung disease. P. aeruginosa secretes various proteases, among them, elastase and protease IV have been found to degrade SP-A and SP-D and abrogate their immune function. However, further investigations are necessary to examine whether these deficiencies facilitate P. aeruginosa infections or stand as consequences.
Keywords
Animals, Bacterial Proteins/metabolism, Cytokines/metabolism, Humans, Lung Diseases/microbiology, Mice, Mice, Knockout, Peptide Hydrolases/metabolism, Phagocytes/physiology, Pseudomonas Infections/*physiopathology, Pseudomonas aeruginosa/enzymology, Pulmonary Surfactant-Associated Protein, A/deficiency/genetics/metabolism/*physiology, Pulmonary Surfactant-Associated Protein B/genetics/metabolism/*physiology, Respiratory Tract Infections/microbiology
Pubmed
Create date
29/04/2021 10:59
Last modification date
30/04/2021 6:38
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