Rise in plasma lactate concentrations with psychosocial stress: a possible sign of cerebral energy demand.

Details

Serval ID
serval:BIB_9F92F186CBD2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Rise in plasma lactate concentrations with psychosocial stress: a possible sign of cerebral energy demand.
Journal
Obesity Facts
Author(s)
Kubera B., Hubold C., Otte S., Lindenberg A.S., Zeiss I., Krause R., Steinkamp M., Klement J., Entringer S., Pellerin L., Peters A.
ISSN
1662-4033 (Electronic)
ISSN-L
1662-4025
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
5
Number
3
Pages
384-392
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Abstract
OBJECTIVE: It is known that exogenous lactate given as an i.v. energy infusion is able to counteract a neuroglycopenic state that developed during psychosocial stress. It is unknown, however, whether the brain under stressful conditions can induce a rise in plasma lactate to satisfy its increased needs during stress. Since lactate is i) an alternative cerebral energy substrate to glucose and ii) its plasmatic concentration is influenced by the sympathetic nervous system, the present study aimed at investigating whether plasma lactate concentrations increase with psychosocial stress in humans.
METHODS: 30 healthy young men participated in two sessions (stress induced by the Trier Social Stress Test and a non-stress control session). Blood samples were frequently taken to assess plasma lactate concentrations and stress hormone profiles.
RESULTS: Plasma lactate increased 47% during psychosocial stress (from 0.9 ± 0.05 to 1.4 ± 0.1 mmol/l; interaction time × stress intervention: F = 19.7, p < 0.001). This increase in lactate concentrations during stress was associated with an increase in epinephrine (R(2) = 0.221, p = 0.02) and ACTH concentrations (R(2) = 0.460, p < 0.001).
CONCLUSION: Plasma lactate concentrations increase during acute psychosocial stress in humans. This finding suggests the existence of a demand mechanism that functions to allocate an additional source of energy from the body towards the brain, which we refer to as 'cerebral lactate demand'.
Keywords
Adolescent, Adrenocorticotropic Hormone/blood, Adult, Brain/metabolism, Energy Metabolism, Epinephrine/blood, Humans, Lactic Acid/blood, Male, Stress, Psychological/blood, Sympathetic Nervous System, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
29/07/2012 14:24
Last modification date
20/08/2019 15:05
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