Effects of gonadotropin-releasing hormone (GnRH) agonist on pituitary and ovarian responses to pulsatile GnRH therapy in polycystic ovarian disease

Details

Serval ID
serval:BIB_9F70EABF3396
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effects of gonadotropin-releasing hormone (GnRH) agonist on pituitary and ovarian responses to pulsatile GnRH therapy in polycystic ovarian disease
Journal
Fertility and Sterility
Author(s)
Surrey  E. S., de Ziegler  D., Lu  J. K., Chang  R. J., Judd  H. L.
ISSN
0015-0282
Publication state
Published
Issued date
10/1989
Peer-reviewed
Oui
Volume
52
Number
4
Pages
547-52
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct
Abstract
Nine clomiphene citrate-resistant polycystic ovarian disease (PCOD) patients received intravenous gonadotropin-releasing hormone (GnRH) pulses before and immediately after 1 month of GnRH agonist (GnRH-a) therapy. Circulating gonadotropin and ovarian steroid levels, as well as follicular development, were measured throughout therapy. Results were compared with those obtained from five hypogonadotropic patients treated with GnRH pulses only who ovulated during six of seven treatment cycles. Only two PCOD patients ovulated normally with GnRH pulses before GnRH-a therapy. Aberrant gonadotropin and ovarian steroid secretory patterns were noted in the others. After GnRH-a, gonadotropin and ovarian steroid hormone levels were similar to those of the hypogonadotropic patients. Subsequent secretory responses to GnRH pulses were partially normalized. However, only two additional PCOD patients ovulated.
Keywords
Amenorrhea/blood/drug therapy/etiology Female Gonadal Steroid Hormones/blood Gonadotropins/blood Humans Hypothalamic Diseases/complications Ovary/*drug effects Pituitary Gland/*drug effects Pituitary Hormone-Releasing Hormones/pharmacology/*therapeutic use Polycystic Ovary Syndrome/*drug therapy Pregnancy Pulsatile Flow
Pubmed
Web of science
Create date
28/02/2008 11:37
Last modification date
20/08/2019 15:05
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