Decrease in hemoglobin levels following surgery influences the outcome in head and neck cancer patients treated with accelerated postoperative radiotherapy.

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Serval ID
serval:BIB_9F24F250B93C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Decrease in hemoglobin levels following surgery influences the outcome in head and neck cancer patients treated with accelerated postoperative radiotherapy.
Journal
Annals of Surgical Oncology
Author(s)
Pehlivan B., Zouhair A., Luthi F., Bron L., Pasche P., Dragusanu D., Azria D., Matzinger O., Mirimanoff R.O., Ozsahin M.
ISSN
1534-4681[electronic], 1068-9265[linking]
Publication state
Published
Issued date
2009
Volume
16
Number
5
Pages
1331-1336
Language
english
Abstract
AIM: To assess the influence of hemoglobin (Hb) levels in locally advanced head and neck cancer (LAHNC) patients treated with surgery and postoperative radiotherapy (PORT). MATERIAL AND METHODS: Pre- and postoperative Hb levels were collected in 79 patients treated with surgery followed by accelerated PORT for LAHNC. Median follow-up was 52 months (range 12-95 months). RESULTS AND DISCUSSION: Four-year overall survival (OS) rate was 51%. Neither pre- nor postoperative Hb level (<120 or 130 g/l in women or men, respectively) influenced the outcome. However, when Hb decrease between pre- and postoperative Hb values was taken into account, 4-year OS was significantly higher in patients with Hb difference less than 38 g/l (quartile value) compared with those with Hb decrease 38 g/l or more (61% versus 16%, P = 0.008). CONCLUSION: Decrease in Hb level by more than 38 g/l after surgery secondary to blood loss influences the outcome when postoperative RT is indicated.
Keywords
Adult, Aged, Aged, 80 and over, Blood Loss, Surgical/mortality, Female, Head and Neck Neoplasms/blood, Head and Neck Neoplasms/mortality, Hemoglobins/analysis, Humans, Male, Middle Aged, Neoplasm Staging, Otorhinolaryngologic Surgical Procedures, Postoperative Care, Radiotherapy, Adjuvant/mortality, Survival Analysis, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
20/02/2009 13:03
Last modification date
01/10/2019 6:19
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