Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice.

Details

Serval ID
serval:BIB_9F14A1A0A39F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice.
Journal
Science
Author(s)
Dudley C.A., Erbel-Sieler C., Estill S.J., Reick M., Franken P., Pitts S., McKnight S.L.
ISSN
1095-9203
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
301
Number
5631
Pages
379-383
Language
english
Abstract
Animal behavior is synchronized to the 24-hour light:dark (LD) cycle by regulatory programs that produce circadian fluctuations in gene expression throughout the body. In mammals, the transcription factor CLOCK controls circadian oscillation in the suprachiasmatic nucleus of the brain; its paralog, neuronal PAS domain protein 2 (NPAS2), performs a similar function in other forebrain sites. To investigate the role of NPAS2 in behavioral manifestations of circadian rhythm, we studied locomotor activity, sleep patterns, and adaptability to both light- and restricted food-driven entrainment in NPAS2-deficient mice. Our results indicate that NPAS2 plays a substantive role in maintaining circadian behaviors in normal LD and feeding conditions and that NPAS2 is critical for adaptability to food restriction.
Keywords
Adaptation, Physiological, Animals, Basic Helix-Loop-Helix Transcription Factors, Behavior, Animal, Biological Clocks, Body Weight, Circadian Rhythm, Crosses, Genetic, Darkness, Eating, Electroencephalography, Electromyography, Female, Food, Gene Targeting, Light, Male, Mice, Mice, Inbred C57BL, Motor Activity, Nerve Tissue Proteins, Prosencephalon, Sleep, Suprachiasmatic Nucleus, Trans-Activators, Transcription Factors
Pubmed
Web of science
Create date
24/01/2008 16:31
Last modification date
03/03/2018 20:02
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