Treatment results of 165 pediatric patients with non-metastatic nasopharyngeal carcinoma: a Rare Cancer Network study

Details

Serval ID
serval:BIB_9E5EEFA888F0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Treatment results of 165 pediatric patients with non-metastatic nasopharyngeal carcinoma: a Rare Cancer Network study
Journal
Radiotherapy and Oncology
Author(s)
Ozyar  E., Selek  U., Laskar  S., Uzel  O., Anacak  Y., Ben-Arush  M., Polychronopoulou  S., Akman  F., Wolden  S. L., Sarihan  S., Miller  R. C., Ozsahin  M., Abacioglu  U., Martin  M., Caloglu  M., Scandolaro  L., Szutowicz  E., Atahan  I. L.
ISSN
0167-8140
Publication state
Published
Issued date
10/2006
Peer-reviewed
Oui
Volume
81
Number
1
Pages
39-46
Notes
Journal Article --- Old month value: Oct
Abstract
PURPOSE: This Rare Cancer Network (RCN) study was performed in pediatric nasopharyngeal carcinoma (PNPC) patients to evaluate the optimal dose of radiotherapy and to determine prognostic factors. PATIENTS AND METHODS: The study included 165 patients with the diagnosis of PNPC treated between 1978 and 2003. The median age was 14 years. There were 3 (1.8%) patients with stage I, 1 (0.6%) with IIA, 10 (6.1%) with IIB, 60 (36.4%) with III, 44 (26.7%) with IVA, and 47 (29%) with IVB disease. While 21 (12.7%) patients were treated with radiotherapy (RT) alone, 144 (87.3%) received chemotherapy and RT. The median follow-up time was 48 months. RESULTS: The actuarial 5-year overall survival (OS) was 77.4% (95% CI: 70.06-84.72), whereas the actuarial 5-year disease-free survival (DFS) rate was 68.8% (95% CI: 61.33-76.31). In multivariate analysis, unfavorable factors were age >14 years for LRC (p=0.04); male gender for DMFS (p=0.03); T3/T4 disease for LRFS (p=0.01); and N3 disease for DFS (p=0.002) and OS (p=0.002); EBRT dose of less than 66 Gy for LRFS (p=0.02) and LRRFS (p=0.0028); and patients treated with RT alone for LRFS (p=0.0001), LRRFS (p=0.007) and DFS (p=0.02). CONCLUSION: Our results support the current practice of using combined radiation and chemotherapy for optimal treatment of NPC. However, research should be encouraged in an attempt to reduce the potential for long-term sequelae in pediatric patients given their relatively favorable prognosis and potential for longevity.
Keywords
Adolescent Age Factors Child Combined Modality Therapy/adverse effects/methods Disease-Free Survival Dose Fractionation Epidemiologic Methods Female Humans Male Nasopharyngeal Neoplasms/drug therapy/mortality/*radiotherapy Neoplasm Recurrence, Local Prognosis Rare Diseases/drug therapy/mortality/*radiotherapy Sex Factors Treatment Outcome
Pubmed
Web of science
Create date
24/01/2008 17:16
Last modification date
20/08/2019 15:04
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