Understanding endometrial physiology and menstrual disorders in the 1990s

Details

Serval ID
serval:BIB_9E49EF42546E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Understanding endometrial physiology and menstrual disorders in the 1990s
Journal
Current Opinion in Obstetrics and Gynecology
Author(s)
de Ziegler  D., Bouchard  P.
ISSN
1040-872X
Publication state
Published
Issued date
06/1993
Peer-reviewed
Oui
Volume
5
Number
3
Pages
378-88
Notes
Journal Article
Review --- Old month value: Jun
Abstract
Two byproducts of in vitro fertilization, transvaginal ultrasonography and hormonal preparation of endometrial receptivity for oocyte donation, have been the source of great progress in endometrial physiology. In practical terms, transvaginal ultrasonography has permitted the assessment of endometrial thickness and more precise echogenicity, the latter being a potential reflector of the secretory changes induced by progesterone. Pulsed and color Doppler ultrasonography have further enhanced the diagnostic performance of transvaginal ultrasonography so that the vascular tone of uterine arteries can be correlated with the hormonal effects on the endometrium and the degree of endometrial receptivity. Because of the excellent pregnancy rates achieved with oocyte donation, estradiol and progesterone replacement regimens have become true experimental models for studying endometrial physiology and physiopathology. Although even extreme alterations in the estradiol-to-progesterone ratio appear to have little effect on endometrial morphology, recent studies suggest an extreme sensitivity of the endometrium to progesterone, particularly early in the luteal phase. The physiology of uterine bleeding and its disorders have been reconsidered in the light of these new findings. In the menstrual cycle, uterine bleeding is triggered by dropping progesterone levels, regardless of estradiol levels.
Keywords
Endometrium/blood supply/drug effects/*physiology/ultrasonography Estrogens/physiology Female Humans Menstruation Disturbances/*physiopathology/ultrasonography Oocytes/*transplantation Ovulation Induction Progesterone/physiology Uterus/blood supply Vascular Resistance
Pubmed
Web of science
Create date
28/02/2008 11:37
Last modification date
20/08/2019 15:04
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