Escape from mineralocorticoid excess: the role of angiotensin II

Details

Serval ID
serval:BIB_9E3D043B6082
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Escape from mineralocorticoid excess: the role of angiotensin II
Journal
Journal of Clinical Endocrinology and Metabolism
Author(s)
Biollaz  J., Durr  J., Brunner  H. R., Porchet  M., Gavras  H.
ISSN
0021-972X (Print)
Publication state
Published
Issued date
06/1982
Volume
54
Number
6
Pages
1187-93
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Jun
Abstract
Escape from the sodium-retaining action of mineralocorticoids coincides with the suppression of plasma renin and angiotensin II levels. The purpose of this study was to evaluate whether blockade of the renin system accelerates this escape. Eight male normotensive volunteers, aged 24--33 yr, were maintained during two subsequent periods of 12 days each, separated by 3--4 weeks, on a constant intake of sodium and potassium of 140 mmol/day. During both periods, fludrocortisone acetate (0.2 mg) was administered orally three times a day on days 4--12. In addition, on days 3--12, either a converting enzyme inhibitor (MK 421;20 mg orally, twice daily) or a placebo was added in double blind fashion and randomized sequence. During both periods, blood pressures were similar; they tended to increase slightly toward day 12. The weight increase did not differ between the two periods. With MK 421, angiotension II levels were significantly lower than with placebo on days 3--6 (P less than 0.001). On the same days, PRA was increased due to converting enzyme blockade. Despite the significantly different angiotensin II levels on days 3--6, daily urinary sodium excretion on all individual days as well as cumulative sodium balance were the same during both periods. Therefore, we could find no evidence in man that suppression of circulating angiotensin II levels is causally related to escape from mineralocorticoid excess.
Keywords
Adult Aldosterone/urine Angiotensin II/blood/*physiology *Blood Pressure Body Weight Creatinine/urine Dipeptides/pharmacology Enalapril Fludrocortisone/*analogs & derivatives/diagnostic use Humans Male Natriuresis Osmolar Concentration Potassium/urine Renin/blood
Pubmed
Web of science
Create date
25/01/2008 10:41
Last modification date
20/08/2019 15:04
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