Secreted aspartic proteases as virulence factors of Candida species

Details

Serval ID
serval:BIB_9E293328B778
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Secreted aspartic proteases as virulence factors of Candida species
Journal
Biological Chemistry
Author(s)
Monod  M., Borg-von  Z. M.
ISSN
1431-6730 (Print)
Publication state
Published
Issued date
08/2002
Volume
383
Number
7-8
Pages
1087-93
Notes
Journal Article
Review --- Old month value: Jul-Aug
Abstract
Candida infections have emerged as a significant medical problem during the last few decades. Among the different virulence traits of C. albicans, secreted proteolytic activity has been intensively investigated. Pathogenesis of the various forms of candidiasis was shown to be associated with the differential and temporal regulation of the expression of genes coding for secreted aspartic proteases (Sap). These enzymes act as cytolysins in macrophages after phagocytosis of Candida, are present in tissue penetration and are also involved in adherence to epithelial cells. Since the introduction of new antiretroviral therapeutics such as HIV protease inhibitors, oropharyngeal candidiasis is less often observed in AIDS patients. Different HIV aspartic protease inhibitors were able to inhibit the C. albicans Saps involved in adherence. The lower rates of oropharyngeal candidiasis observed in individuals receiving antiretroviral combination therapy could reflect not only an improvement in the immune system but also direct inhibition of Candida Saps by HIV protease inhibitors. Therefore, the development of specific aspartic protease inhibitors might be of interest for the inhibition of candidiasis.
Keywords
Animals Aspartic Endopeptidases/*physiology/secretion Candida/*enzymology/pathogenicity Candidiasis/enzymology/immunology Humans Substrate Specificity Virulence Factors
Pubmed
Web of science
Create date
25/01/2008 16:46
Last modification date
20/08/2019 15:04
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