Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity.

Details

Serval ID
serval:BIB_9E018D638DDB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity.
Journal
Scientific reports
Author(s)
Ayrignac X., Le Bars E., Duflos C., Hirtz C., Maleska Maceski A., Carra-Dallière C., Charif M., Pinna F., Prin P., Menjot de Champfleur N., Deverdun J., Kober T., Marechal B., Fartaria M.J., Corredor Jerez R., Labauge P., Lehmann S.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
02/07/2020
Peer-reviewed
Oui
Volume
10
Number
1
Pages
10923
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Neurofilament light chain (NfL) has been demonstrated to correlate with multiple sclerosis disease severity as well as treatment response. Nevertheless, additional serum biomarkers are still needed to better differentiate disease activity from disease progression. The aim of our study was to assess serum glial fibrillary acid protein (s-GFAP) and neurofilament light chain (s-NfL) in a cohort of 129 multiple sclerosis (MS) patients. Eighteen primary progressive multiple sclerosis (PPMS) and 111 relapsing remitting MS (RRMS) were included. We showed that these 2 biomarkers were significantly correlated with each other (R = 0.72, p < 0.001). Moreover, both biomarkers were higher in PPMS than in RRMS even if multivariate analysis only confirmed this difference for s-GFAP (130.3 ± 72.8 pg/ml vs 83.4 ± 41.1 pg/ml, p = 0.008). Finally, s-GFAP was correlated with white matter lesion load and inversely correlated with WM and GM volume. Our results seem to confirm the added value of s-GFAP in the context of multiple sclerosis.
Keywords
Adult, Brain/pathology, Cross-Sectional Studies, Female, Glial Fibrillary Acidic Protein/blood, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Chronic Progressive/blood, Multiple Sclerosis, Chronic Progressive/pathology, Multiple Sclerosis, Relapsing-Remitting/blood, Multiple Sclerosis, Relapsing-Remitting/pathology, Neurofilament Proteins/blood, Severity of Illness Index, White Matter/pathology
Pubmed
Web of science
Open Access
Yes
Create date
08/07/2020 13:00
Last modification date
06/04/2024 7:23
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