Antimicrobial resistance of Staphylococcus aureus strains acquired by pig farmers from pigs

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Version: Author's accepted manuscript
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State: Public
Version: Final published version
Serval ID
serval:BIB_9DE189BA370D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antimicrobial resistance of Staphylococcus aureus strains acquired by pig farmers from pigs
Journal
Applied and Environmental Microbiology
Author(s)
Oppliger Anne, Moreillon Philippe, Charrière Nicole, Giddey Marlyse, Morisset Delphine, Sakwinska Olga
ISSN
1098-5336 (Electronic)
ISSN-L
0099-2240
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
78
Number
22
Pages
8010-8014
Language
english
Abstract
Carriage of animal-associated methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 398 (CC398) is common among pig farmers. This study was conducted (i) to investigate whether pig farmers are colonized with pig-specific S. aureus genotypes other than CC398 and (ii) to survey antimicrobial resistance of S. aureus isolates from pigs and pig farmers. Forty-eight S. aureus isolates from pig farmers and veterinarians and 130 isolates from pigs collected in Western Switzerland were genotyped by spa typing and amplified fragment length polymorphism (AFLP). Antimicrobial resistance profiles were determined for representative sample of the isolates. The data obtained earlier on healthy S. aureus carriers without exposure to agriculture were used for comparison. The genotype composition of S. aureus isolates from pig farmers and veterinarians was similar to isolates from pigs with predominant AFLP clusters CC398, CC9, and CC49. The resistance to tetracycline and macrolides (clarithromycin) was common among the isolates from farmers and veterinarians (52 and 21%, respectively) and similar to resistance levels in isolates from pigs (39 and 23%, respectively). This was in contrast to isolates from persons without contact with agriculture, where no (0/128) isolates were resistant to tetracycline and 3% of the isolates were resistant to clarithromycin. MRSA CC398 was isolated from pigs (n = 11) and pig farmers (n = 5). These data imply that zoonotic transmission of multidrug-resistant S. aureus from pigs to farmers is frequent, and well-known MRSA transmission merely represents the tip of the iceberg for this phenomenon. We speculate that the relatively low frequency of MRSA isolation is related to lower antimicrobial use in Switzerland compared to, for example, the Netherlands.
Keywords
Methicillin-Resistant Staphylococcus aureus, Staphylococcus aureus, Swine, Agriculture, Occupational Exposure,
Pubmed
Web of science
Open Access
Yes
Create date
20/12/2012 18:50
Last modification date
20/08/2019 15:04
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