Determinants of microdamage in elderly human vertebral trabecular bone.

Details

Serval ID
serval:BIB_9DDD381D52B0
Type
Article: article from journal or magazin.
Collection
Publications
Title
Determinants of microdamage in elderly human vertebral trabecular bone.
Journal
PloS one
Author(s)
Follet H., Farlay D., Bala Y., Viguet-Carrin S., Gineyts E., Burt-Pichat B., Wegrzyn J., Delmas P., Boivin G., Chapurlat R.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
8
Number
2
Pages
e55232
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Previous studies have shown that microdamage accumulates in bone as a result of physiological loading and occurs naturally in human trabecular bone. The purpose of this study was to determine the factors associated with pre-existing microdamage in human vertebral trabecular bone, namely age, architecture, hardness, mineral and organic matrix. Trabecular bone cores were collected from human L2 vertebrae (n = 53) from donors 54-95 years of age (22 men and 30 women, 1 unknown) and previous cited parameters were evaluated. Collagen cross-link content (PYD, DPD, PEN and % of collagen) was measured on surrounding trabecular bone. We found that determinants of microdamage were mostly the age of donors, architecture, mineral characteristics and mature enzymatic cross-links. Moreover, linear microcracks were mostly associated with the bone matrix characteristics whereas diffuse damage was associated with architecture. We conclude that linear and diffuse types of microdamage seemed to have different determinants, with age being critical for both types.
Keywords
Age Factors, Aged, Aged, 80 and over, Bone Density, Calcification, Physiologic, Collagen/analysis, Female, Hardness, Humans, Male, Middle Aged, Minerals/analysis, Spine/chemistry, Spine/pathology, Spine/ultrastructure
Pubmed
Web of science
Open Access
Yes
Create date
17/01/2020 8:06
Last modification date
18/01/2020 6:26
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