Reproducibility and discriminating ability of fluorine-18-6-fluoro-L-Dopa PET in Parkinson's disease

Details

Serval ID
serval:BIB_9DD731E460D3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Reproducibility and discriminating ability of fluorine-18-6-fluoro-L-Dopa PET in Parkinson's disease
Journal
Journal of Nuclear Medicine
Author(s)
Vingerhoets  F. J., Schulzer  M., Ruth  T. J., Holden  J. E., Snow  B. J.
ISSN
0161-5505 (Print)
Publication state
Published
Issued date
03/1996
Volume
37
Number
3
Pages
421-6
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Abstract
Fluorine-18-fluorodopa (F-Dopa) PET assesses the integrity of the nigrostriatal dopaminergic neurons in Parkinson's disease. It has been used in longitudinal studies to measure the progression of Parkinson's disease and the effects of medications and intracerebral transplants. The significance of changes in PET indices in such studies depends largely on the reproducibility of the F-Dopa PET measurements. METHODS: We performed repeated F-Dopa PET scans in 12 subjects with Parkinson's disease (between Hoehn and Yahr stages I and III) to measure scan-to-scan variations. Data were analyzed using five methods comprising two sets of regions of interest (ROIs) (total striatum and substriatal), the striatum-to-cortex ratio and two graphical methods (one using plasma radioactivity, the other using cortical radioactivity as the input function). We also studied the effectiveness of each method in discriminating between patients with Parkinson's disease and normal subjects using data obtained from a similar study in 10 normal subjects. RESULTS: We found reliability coefficients between 66% and 93%; the scan-to-scan intrasubject standard deviation ranged from 2% to 16% of the mean value depending on the method of analysis and the size of the ROIs. All methods discriminated significantly between patients with Parkinson's disease and normal subjects. The ability to discriminate, as reflected by the intergroup/intragroup ratio of variance, ranged from 2 to 18. CONCLUSION: These results permit selection of the best method of analysis for studies of nigrostriatal dopaminergic function.
Keywords
Analysis of Variance Brain/*radionuclide imaging Case-Control Studies Dihydroxyphenylalanine/*analogs & derivatives/diagnostic use Female Fluorine Radioisotopes/*diagnostic use Follow-Up Studies Humans Male Middle Aged Parkinson Disease/epidemiology/*radionuclide imaging Reproducibility of Results Time Factors *Tomography, Emission-Computed/methods
Pubmed
Web of science
Create date
25/01/2008 12:49
Last modification date
20/08/2019 15:04
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