Omega-3 fatty acids predict recurrent venous thromboembolism or total mortality in elderly patients with acute venous thromboembolism.

Details

Serval ID
serval:BIB_9DD46C477648
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Omega-3 fatty acids predict recurrent venous thromboembolism or total mortality in elderly patients with acute venous thromboembolism.
Journal
Journal of thrombosis and haemostasis
Author(s)
Reiner M.F., Stivala S., Limacher A., Bonetti N.R., Méan M., Egloff M., Rodondi N., Aujesky D., von Schacky C., Lüscher T.F., Camici G.G., Beer J.H.
ISSN
1538-7836 (Electronic)
ISSN-L
1538-7836
Publication state
Published
Issued date
01/2017
Peer-reviewed
Oui
Volume
15
Number
1
Pages
47-56
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
Essentials The role of omega-3 fatty acids (n-3 FAs) in recurrent venous thromboembolism (VTE) is unknown. Association of n-3 FAs with recurrent VTE or total mortality was investigated in 826 patients. Whole blood n-3 FAs were inversely correlated with recurrent VTE or total mortality. Major and non-major bleeding was not increased in patients with higher levels of n-3 FAs.
Background The role of omega-3 fatty acids (n-3 FAs) in recurrent venous thromboembolism (VTE) remains unknown. Objectives To investigate the association of n-3 FAs with recurrent VTE or total mortality at 6 months and 3 years. Methods N-3 FAs were assessed in 826 patients aged ≥ 65 years, categorized into low, medium and high based on the 25th and 75th percentile. Mean follow-up was 29 months. Results At 6 months, subjects with medium (adjusted hazard ratio [HR], 0.37; 95% confidence interval [CI], 0.22-0.62) and high n-3 FA levels (adjusted HR, 0.36; 95% CI, 0.20-0.67) were less likely to develop recurrent VTE or total mortality, compared with those with low n-3 FAs. At 3 years, medium levels (adjusted HR, 0.67; 95% CI, 0.47-0.96) were associated with lower risk of recurrent VTE or total mortality. As compared with low n-3 FAs, the adjusted sub-hazard ratio [SHR] of recurrent VTE was 0.39 (95% CI, 0.15-0.99) in patients with medium and 0.17 (95% CI, 0.03-0.82) in patients with high n-3 FAs. The cumulative incidence of recurrent VTE was lower in the medium and high n-3 FA groups as compared with the low n-3 FA groups, but seems to have worn off after 3 years. The incidence of major and non-major bleeding was not greater in the high n-3 FA group. Conclusion Higher levels of n-3 FAs were associated with a lower risk of recurrent VTE or total mortality in elderly patients with VTE, but not with greater bleeding risk.

Keywords
Acute Disease, Aged, Aged, 80 and over, Fatty Acids, Omega-3/blood, Female, Follow-Up Studies, Hemorrhage, Humans, Kaplan-Meier Estimate, Male, Mortality, Neoplasms/complications, Proportional Hazards Models, Prospective Studies, Pulmonary Embolism/drug therapy, Recurrence, Risk Factors, Venous Thromboembolism/epidemiology, bleeding, deep vein thrombosis, omega-3 fatty acids, pulmonary embolism, recurrent venous thromboembolism
Pubmed
Web of science
Open Access
Yes
Create date
06/01/2017 8:26
Last modification date
20/08/2019 15:04
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