Acquisition of Extended-Spectrum β-Lactamase GES-6 Leading to Resistance to Ceftolozane-Tazobactam Combination in Pseudomonas aeruginosa.

Details

Serval ID
serval:BIB_9DD0E482BDD8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Acquisition of Extended-Spectrum β-Lactamase GES-6 Leading to Resistance to Ceftolozane-Tazobactam Combination in Pseudomonas aeruginosa.
Journal
Antimicrobial agents and chemotherapy
Author(s)
Poirel L., Ortiz De La Rosa J.M., Kieffer N., Dubois V., Jayol A., Nordmann P.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
01/2019
Peer-reviewed
Oui
Volume
63
Number
1
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
A clinical Pseudomonas aeruginosa isolate resistant to all β-lactams, including ceftolozane-tazobactam and carbapenems, was recovered. It belonged to sequence type 235 and produced the extended-spectrum β-lactamase (ESBL) GES-6 differing from GES-1 by two amino acid substitutions (E104K and G170S). GES-6 possessed an increased hydrolytic activity toward carbapenems and to ceftolozane and a decreased susceptibility to β-lactamase inhibitors compared to GES-1, except for avibactam. We show here that resistance to ceftolozane-tazobactam may occur through acquisition of a specific ESBL in P. aeruginosa but that ceftazidime-avibactam combination remains an effective alternative.
Keywords
Amino Acid Substitution, Anti-Bacterial Agents/pharmacology, Azabicyclo Compounds/pharmacology, Carbapenems/pharmacology, Ceftazidime/pharmacology, Cephalosporins/pharmacology, Drug Combinations, Gene Expression, Humans, Microbial Sensitivity Tests, Pseudomonas Infections/drug therapy, Pseudomonas Infections/microbiology, Pseudomonas aeruginosa/drug effects, Pseudomonas aeruginosa/enzymology, Pseudomonas aeruginosa/genetics, Pseudomonas aeruginosa/isolation & purification, Tazobactam/pharmacology, beta-Lactam Resistance/drug effects, beta-Lactam Resistance/genetics, beta-Lactamases/genetics, beta-Lactamases/metabolism, ESBL, GES-6, Pseudomonas aeruginosa, ceftolozane-tazobactam
Pubmed
Web of science
Open Access
Yes
Create date
30/10/2018 11:46
Last modification date
23/01/2020 6:19
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