Determination of catecholamines in plasma and urine.

Details

Serval ID
serval:BIB_9DC4192A17AD
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Determination of catecholamines in plasma and urine.
Journal
Best Practice and Research. Clinical Endocrinology and Metabolism
Author(s)
Grouzmann E., Lamine F.
ISSN
1878-1594 (Electronic)
ISSN-L
1521-690X
Publication state
Published
Issued date
2013
Volume
27
Number
5
Pages
713-723
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
For more than 20 years, measurement of catecholamines in plasma and urine in clinical chemistry laboratories has been the cornerstone of the diagnosis of neuroendocrine tumors deriving from the neural crest such as pheochromocytoma (PHEO) and neuroblastoma (NB), and is still used to assess sympathetic stress function in man and animals. Although assay of catecholamines in urine are still considered the biochemical standard for the diagnosis of NB, they have been progressively abandoned for excluding/confirming PHEOs to the advantage of metanephrines (MNs). Nevertheless, catecholamine determinations are still of interest to improve the biochemical diagnosis of PHEO in difficult cases that usually require a clonidine-suppression test, or to establish whether a patient with PHEO secretes high concentrations of catecholamines in addition to metanephrines. The aim of this chapter is to provide an update about the catecholamine assays in plasma and urine and to show the most common pre-analytical and analytical pitfalls associated with their determination.
Pubmed
Web of science
Create date
01/12/2013 15:23
Last modification date
20/08/2019 15:04
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