In vitro whole-genome analysis identifies a susceptibility locus for HIV-1.

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Serval ID
serval:BIB_9DB3D3F376D3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
In vitro whole-genome analysis identifies a susceptibility locus for HIV-1.
Journal
PLoS Biology
Author(s)
Loeuillet C., Deutsch S., Ciuffi A., Robyr D., Taffé P., Muñoz M., Beckmann J.S., Antonarakis S.E., Telenti A.
ISSN
1545-7885
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
6
Number
2
Pages
e32
Language
english
Abstract
Advances in large-scale analysis of human genomic variability provide unprecedented opportunities to study the genetic basis of susceptibility to infectious agents. We report here the use of an in vitro system for the identification of a locus on HSA8q24.3 associated with cellular susceptibility to HIV-1. This locus was mapped through quantitative linkage analysis using cell lines from multigeneration families, validated in vitro, and followed up by two independent association studies in HIV-positive individuals. Single nucleotide polymorphism rs2572886, which is associated with cellular susceptibility to HIV-1 in lymphoblastoid B cells and in primary T cells, was also associated with accelerated disease progression in one of two cohorts of HIV-1-infected patients. Biological analysis suggests a role of the rs2572886 region in the regulation of the LY6 family of glycosyl-phosphatidyl-inositol (GPI)-anchored proteins. Genetic analysis of in vitro cellular phenotypes provides an attractive approach for the discovery of susceptibility loci to infectious agents.
Keywords
Chromosome Mapping, Cohort Studies, Genetic Predisposition to Disease, Genome, Human, Glycosylphosphatidylinositols, HIV Infections, HIV-1, Humans
Pubmed
Web of science
Open Access
Yes
Create date
20/02/2009 13:30
Last modification date
20/08/2019 15:04
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