mtDB: Human Mitochondrial Genome Database, a resource for population genetics and medical sciences

Details

Ressource 1Download: 16381973_BIB_9D7629A62E8C.pdf (119.97 [Ko])
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_9D7629A62E8C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
mtDB: Human Mitochondrial Genome Database, a resource for population genetics and medical sciences
Journal
Nucleic Acids Research
Author(s)
Ingman M., Gyllensten U.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Publication state
Published
Issued date
2006
Volume
34
Number
Database issue
Pages
D749-D751
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The mitochondrial genome, contained in the subcellular mitochondrial network, encodes a small number of peptides pivotal for cellular energy production. Mitochondrial genes are highly polymorphic and cataloguing existing variation is of interest for medical scientists involved in the identification of mutations causing mitochondrial dysfunction, as well as for population genetics studies. Human Mitochondrial Genome Database (mtDB) (http://www.genpat.uu.se/mtDB) has provided a comprehensive database of complete human mitochondrial genomes since early 2000. At this time, owing to an increase in the number of published complete human mitochondrial genome sequences, it became necessary to provide a web-based database of human whole genome and complete coding region sequences. As of August 2005 this database contains 2104 sequences (1544 complete genome and 560 coding region) available to download or search for specific polymorphisms. Of special interest to medical researchers and population geneticists evaluating specific positions is a complete list of (currently 3311) mitochondrial polymorphisms among these sequences. Recent expansions in the capabilities of mtDB include a haplotype search function and the ability to identify and download sequences carrying particular variants.
Keywords
Mitochondria/genetics, Mitochondrial Diseases/genetics
Pubmed
Web of science
Open Access
Yes
Create date
13/07/2018 9:00
Last modification date
20/08/2019 15:03
Usage data