Detection of Ureaplasma urealyticum in second-trimester amniotic fluid by polymerase chain reaction correlates with subsequent preterm labor and delivery

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Serval ID
serval:BIB_9D634B2CD24B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Detection of Ureaplasma urealyticum in second-trimester amniotic fluid by polymerase chain reaction correlates with subsequent preterm labor and delivery
Journal
Journal of Infectious Diseases
Author(s)
Gerber  S., Vial  Y., Hohlfeld  P., Witkin  S. S.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
02/2003
Volume
187
Number
3
Pages
518-21
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Feb 1
Abstract
Ureaplasma urealyticum is the microorganism most frequently isolated from the amniotic fluid of women in preterm labor. The relationship between intra-amniotic U. urealyticum in healthy second-trimester pregnant women and subsequent pregnancy outcome was investigated. Transabdominal amniotic fluid obtained from 254 asymptomatic women at 15-17 weeks' gestation were tested by polymerase chain reaction (PCR). U. urealyticum was identified in 29 subjects (11.4%). A subsequent preterm labor occurred in 17 U. urealyticum-positive women (58.6%), compared with 10 (4.4%) U. urealyticum-negative women (P<.0001). Preterm birth was documented in 7 (24.1%) U. urealyticum-positive women compared with only 1 U. urealyticum-negative woman (0.4%) (P<.0001). U. urealyticum-positive women also had a higher prevalence of preterm labor in a prior pregnancy (20.7%) than did the negative women (2.7%; P=.0008). PCR testing of second-trimester amniotic fluid for U. urealyticum can identify women at risk for subsequent preterm labor and delivery.
Keywords
Adult Amniotic Fluid/*microbiology *Delivery, Obstetric Female Humans Obstetric Labor, Premature/*complications/epidemiology/*microbiology Polymerase Chain Reaction Pregnancy Pregnancy Complications, Infectious/diagnosis/epidemiology/*microbiology Pregnancy Trimester, Second Prevalence Ureaplasma Infections/*complications/diagnosis/epidemiology/microbiology Ureaplasma urealyticum/genetics/*isolation & purification
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 11:12
Last modification date
25/09/2019 6:10
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