Reduced-antigen-content-diphtheria-tetanus-acellular-pertussis and inactivated polio vaccine as a booster for adolescents 10 to 14 years of age

Details

Serval ID
serval:BIB_9D57C16761DF
Type
Article: article from journal or magazin.
Collection
Publications
Title
Reduced-antigen-content-diphtheria-tetanus-acellular-pertussis and inactivated polio vaccine as a booster for adolescents 10 to 14 years of age
Journal
European Journal of Pediatrics
Author(s)
Vergara  R., Tregnaghi  M., Ussher  J., Navarro  S., Ruttimann  R., Potin  M., Wolter  J., Schuerman  L.
ISSN
0340-6199 (Print)
Publication state
Published
Issued date
06/2005
Volume
164
Number
6
Pages
377-82
Notes
Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Jun
Abstract
High rates of pertussis disease in adolescents suggest that additional boosting against pertussis would be beneficial. A combined acellular-pertussis-containing booster vaccine (dTpa-IPV; Boostrixtrade mark Polio, n =440) was compared to separately administered dTpa (Boostrixtrade mark) and inactivated polio virus (IPV; Imovax Polio((R)), n =219), and to DTPa-IPV (Infanrixtrade mark IPV, n =111) vaccine in a partially blind, randomised controlled trial in 10-14 year olds. One month after vaccination, seroprotection/seropositivity rates for all antigens were similar for all groups. Although pertussis and diphtheria antibody geometric mean antibody concentrations were higher after DTPa-IPV, all subjects had protective antibodies against diphtheria, tetanus and polio, and at least 97% had a vaccine response to pertussis antigens. Reactogenicity of dTpa-IPV was comparable to dTpa + IPV, but dTpa-IPV was generally better tolerated than DTPa-IPV. CONCLUSION: The combined reduced-antigen-content-diphtheria-tetanus-acellular-pertussis and IPV vaccine is immunogenic and well tolerated when administered to adolescents and could be used to improve the control of pertussis disease in this age group.
Keywords
Adolescent Analysis of Variance Antibody Formation Child Diphtheria-Tetanus-acellular Pertussis Vaccines/*administration & dosage/adverse effects/immunology Double-Blind Method Humans *Immunization, Secondary Poliovirus Vaccine, Inactivated/*administration & dosage/adverse effects/immunology Safety Vaccines, Combined/adverse effects/immunology
Pubmed
Web of science
Create date
24/01/2008 20:10
Last modification date
20/08/2019 15:03
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