Patterns of calcium-binding proteins in human inferior colliculus: identification of subdivisions and evidence for putative parallel systems.

Details

Serval ID
serval:BIB_9D430CDB7F62
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Patterns of calcium-binding proteins in human inferior colliculus: identification of subdivisions and evidence for putative parallel systems.
Journal
Neuroscience
Author(s)
Tardif E., Chiry O., Probst A., Magistretti P.J., Clarke S.
ISSN
0306-4522
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
116
Number
4
Pages
1111-1121
Language
english
Abstract
The subdivisions of human inferior colliculus are currently based on Golgi and Nissl-stained preparations. We have investigated the distribution of calcium-binding protein immunoreactivity in the human inferior colliculus and found complementary or mutually exclusive localisations of parvalbumin versus calbindin D-28k and calretinin staining. The central nucleus of the inferior colliculus but not the surrounding regions contained parvalbumin-positive neuronal somata and fibres. Calbindin-positive neurons and fibres were concentrated in the dorsal aspect of the central nucleus and in structures surrounding it: the dorsal cortex, the lateral lemniscus, the ventrolateral nucleus, and the intercollicular region. In the dorsal cortex, labelling of calbindin and calretinin revealed four distinct layers.Thus, calcium-binding protein reactivity reveals in the human inferior colliculus distinct neuronal populations that are anatomically segregated. The different calcium-binding protein-defined subdivisions may belong to parallel auditory pathways that were previously demonstrated in non-human primates, and they may constitute a first indication of parallel processing in human subcortical auditory structures.
Keywords
Adult, Aged, Aged, 80 and over, Calcium-Binding Proteins, Female, Humans, Inferior Colliculi, Male, Neurons
Pubmed
Web of science
Create date
22/01/2008 15:34
Last modification date
20/08/2019 16:03
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