Heart rate variability and peripheral nerve conduction velocity in relation to blood lead in newly hired lead workers.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_9D3353C7F5F2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Heart rate variability and peripheral nerve conduction velocity in relation to blood lead in newly hired lead workers.
Journal
Occupational and environmental medicine
Author(s)
Yu C.G., Wei F.F., Yang W.Y., Zhang Z.Y., Mujaj B., Thijs L., Feng Y.M., Staessen J.A.
ISSN
1470-7926 (Electronic)
ISSN-L
1351-0711
Publication state
Published
Issued date
06/2019
Peer-reviewed
Oui
Volume
76
Number
6
Pages
382-388
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Previous studies relating nervous activity to blood lead (BL) levels have limited relevance, because over time environmental and occupational exposure substantially dropped. We investigated the association of heart rate variability (HRV) and median nerve conduction velocity (NCV) with BL using the baseline measurements collected in the Study for Promotion of Health in Recycling Lead (NCT02243904).
In 328 newly hired men (mean age 28.3 years; participation rate 82.7%), we derived HRV measures (power expressed in normalised units (nu) in the high-frequency (HF) and low-frequency (LF) domains, and LF/HF) prior to long-term occupational lead exposure. Five-minute ECG recordings, obtained in the supine and standing positions, were analysed by Fourier transform or autoregressive modelling, using Cardiax software. Motor NCV was measured at the median nerve by a handheld device (Brevio Nerve Conduction Monitoring System, NeuMed, West Trenton, NJ, USA). BL was determined by inductively coupled plasma mass spectrometry.
Mean BL was 4.54 µg/dL (IQR 2.60-8.90 µg/dL). Mean supine and standing values of LF, HF and LF/HF were 50.5 and 21.1 nu and 2.63, and 59.7 and 10.9 nu and 6.31, respectively. Orthostatic stress decreased HF and increased LF (p<0.001). NCV averaged 3.74 m/s. Analyses across thirds of the BL distribution and multivariable-adjusted regression analyses failed to demonstrate any association of HRV or NCV with BL.
At the exposure levels observed in our study, autonomous nervous activity and NCV were not associated with BL.
NCT02243904.
Keywords
Adult, Blood Pressure Determination/methods, Electrocardiography/methods, Female, Heart Rate/physiology, Humans, Lead/analysis, Lead/blood, Male, Metallurgy/statistics & numerical data, Neural Conduction/physiology, Peripheral Nerves/metabolism, Peripheral Nerves/physiology, cardiovascular, healthcare workers, lead, materials, exposures and occupational groups, neurophysiology
Pubmed
Web of science
Open Access
Yes
Create date
15/04/2019 8:53
Last modification date
11/01/2020 6:16
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