TDM in psychiatry and neurology: A comprehensive summary of the consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology, update 2017; a tool for clinicians<sup/>.

Details

Serval ID
serval:BIB_9D1041ED4C31
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
TDM in psychiatry and neurology: A comprehensive summary of the consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology, update 2017; a tool for clinicians<sup/>.
Journal
The world journal of biological psychiatry
Author(s)
Schoretsanitis G., Paulzen M., Unterecker S., Schwarz M., Conca A., Zernig G., Gründer G., Haen E., Baumann P., Bergemann N., Clement H.W., Domschke K., Eckermann G., Egberts K., Gerlach M., Greiner C., Havemann-Reinecke U., Hefner G., Helmer R., Janssen G., Jaquenoud-Sirot E., Laux G., Messer T., Mössner R., Müller M.J., Pfuhlmann B., Riederer P., Saria A., Schoppek B., Silva Gracia M., Stegmann B., Steimer W., Stingl J.C., Uhr M., Ulrich S., Waschgler R., Zurek G., Hiemke C.
ISSN
1814-1412 (Electronic)
ISSN-L
1562-2975
Publication state
Published
Issued date
04/2018
Peer-reviewed
Oui
Volume
19
Number
3
Pages
162-174
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Therapeutic drug monitoring (TDM) combines the quantification of drug concentrations in blood, pharmacological interpretation and treatment guidance. TDM introduces a precision medicine tool in times of increasing awareness of the need for personalized treatment. In neurology and psychiatry, TDM can guide pharmacotherapy for patient subgroups such as children, adolescents, pregnant women, elderly patients, patients with intellectual disabilities, patients with substance use disorders, individuals with pharmacokinetic peculiarities and forensic patients. Clear indications for TDM include lack of clinical response in the therapeutic dose range, assessment of drug adherence, tolerability issues and drug-drug interactions.
Based upon existing literature, recommended therapeutic reference ranges, laboratory alert levels, and levels of recommendation to use TDM for dosage optimization without specific indications, conversion factors, factors for calculation of dose-related drug concentrations and metabolite-to-parent ratios were calculated.
This summary of the updated consensus guidelines by the TDM task force of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie offers the practical and theoretical knowledge for the integration of TDM as part of pharmacotherapy with neuropsychiatric agents into clinical routine.
The present guidelines for TDM application for neuropsychiatric agents aim to assist clinicians in enhancing safety and efficacy of treatment.
Keywords
Consensus, Drug Monitoring/standards, Humans, Neurology/standards, Practice Guidelines as Topic/standards, Psychiatry/standards, Psychopharmacology/standards, Therapeutic drug monitoring, drug therapy, neuropsychopharmacology, pharmacokinetics, pharmacovigilance
Pubmed
Web of science
Create date
10/03/2018 10:41
Last modification date
20/08/2019 15:03
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