EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis.

Details

Serval ID
serval:BIB_9CFD784AB79A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis.
Journal
Annals of the Rheumatic Diseases
Author(s)
Zhang W., Doherty M., Peat G., Bierma-Zeinstra M.A., Arden N.K., Bresnihan B., Herrero-Beaumont G., Kirschner S., Leeb B.F., Lohmander L.S., Mazières B., Pavelka K., Punzi L., So A.K., Tuncer T., Watt I., Bijlsma J.W.
ISSN
1468-2060[electronic], 0003-4967[linking]
Publication state
Published
Issued date
2010
Volume
69
Number
3
Pages
483-489
Language
english
Abstract
OBJECTIVE: To develop evidence-based recommendations for the diagnosis of knee osteoarthritis (OA). METHODS: The multidisciplinary guideline development group, representing 12 European countries, generated 10 key propositions regarding diagnosis using a Delphi consensus approach. For each recommendation, research evidence was searched systematically. Whenever possible, the sensitivity, specificity and likelihood ratio were calculated for individual diagnostic indicators and a diagnostic ladder was developed using Bayes' method. Secondary analyses were undertaken to test directly the recommendations using multiple predictive models in two populations from the UK and the Netherlands. Strength of recommendation was assessed by the EULAR visual analogue scale. RESULTS: Recommendations covered the definition of knee OA and its risk factors, subsets, typical symptoms and signs, the use of imaging and laboratory tests and differential diagnosis. Three symptoms (persistent knee pain, limited morning stiffness and reduced function) and three signs (crepitus, restricted movement and bony enlargement) appeared to be the most useful. Assuming a 12.5% background prevalence of knee OA in adults aged > or =45 years, the estimated probability of having radiographic knee OA increased with increasing number of positive features, to 99% when all six symptoms and signs were present. The performance of the recommendations in the study populations varied according to the definition of knee OA, background risk and number of tests applied. CONCLUSION: 10 key recommendations for diagnosis of knee OA were developed using both research evidence and expert consensus. Although there is no agreed reference standard, thorough clinical assessment alone can provide a confident rule-in diagnosis.
Keywords
Adult, Aged, Aged, 80 and over, Diagnosis, Differential, Epidemiologic Methods, Evidence-Based Medicine, Female, Humans, Male, Middle Aged, Osteoarthritis, Knee/diagnosis, Practice Guidelines as Topic, Young Adult
Pubmed
Web of science
Create date
12/02/2010 13:09
Last modification date
20/08/2019 15:03
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