Olfactory receptor-dependent receptor repression in Drosophila.

Details

Serval ID
serval:BIB_9CEC0BBE9EE9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Olfactory receptor-dependent receptor repression in Drosophila.
Journal
Science advances
Author(s)
Mika K., Cruchet S., Chai P.C., Prieto-Godino L.L., Auer T.O., Pradervand S., Benton R.
ISSN
2375-2548 (Electronic)
ISSN-L
2375-2548
Publication state
Published
Issued date
08/2021
Peer-reviewed
Oui
Volume
7
Number
32
Pages
eabe3745
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
In olfactory systems across phyla, most sensory neurons express a single olfactory receptor gene selected from a large genomic repertoire. We describe previously unknown receptor gene-dependent mechanisms that ensure singular expression of receptors encoded by a tandem gene array [Ionotropic receptor 75c (Ir75c), Ir75b, and Ir75a, organized 5' to 3'] in Drosophila melanogaster Transcription from upstream genes in the cluster runs through the coding region of downstream loci and inhibits their expression in cis, most likely via transcriptional interference. Moreover, Ir75c blocks accumulation of other receptor proteins in trans through a protein-dependent, posttranscriptional mechanism. These repression mechanisms operate in endogenous neurons, in conjunction with cell type-specific gene regulatory networks, to ensure unique receptor expression. Our data provide evidence for inter-olfactory receptor regulation in invertebrates and highlight unprecedented, but potentially widespread, mechanisms for ensuring exclusive expression of chemosensory receptors, and other protein families, encoded by tandemly arranged genes.
Pubmed
Web of science
Open Access
Yes
Create date
28/04/2021 6:59
Last modification date
21/08/2021 6:36
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