Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: results of the Swiss SAPALDIA study

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Serval ID
serval:BIB_9CB899C36F58
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: results of the Swiss SAPALDIA study
Journal
Nephrology, Dialysis, Transplantation
Author(s)
Nitsch  D., Felber Dietrich  D., von Eckardstein  A., Gaspoz  J. M., Downs  S. H., Leuenberger  P., Tschopp  J. M., Brandli  O., Keller  R., Gerbase  M. W., Probst-Hensch  N. M., Stutz  E. Z., Ackermann-Liebrich  U.
ISSN
0931-0509 (Print)
Publication state
Published
Issued date
04/2006
Volume
21
Number
4
Pages
935-44
Notes
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
BACKGROUND: Impaired renal function is evolving as an independent marker of the risk of cardiovascular morbidity and mortality. Little is known about the prevalence of impaired renal function and its relationship to cardiovascular risk factors in the Swiss general population. METHODS: SAPALDIA comprises a random sample of the Swiss population established in 1991, originally to investigate the health effects of long-term exposure to air pollution. Participants were reassessed in 2002/3 and blood measurements were obtained (n = 6317). Renal function was estimated using the Cockcroft-Gault equation and the modified MDRD (four-component) equation incorporating age, race, gender and serum creatinine level. RESULTS: The estimated prevalence of impaired renal function [estimated glomerular filtration rate <60 ml/min/1.73 m(2)] differed substantially between men and women, particularly at higher ages, and amounted to 13% [95% confidence interval (CI) 10-16%] and 36% (95% CI 32-40%) in men and women, respectively, of 65 years or older. Smoking, obesity, blood lipid levels, high systolic blood pressure and hyperuricaemia were all more common in men when compared with women. These cardiovascular risk factors were also associated independently with creatinine in both women and men. Women were less likely to receive cardiovascular drugs, in particular angiotensin-converting enzyme inhibitors and beta-blockers, when compared with men of the same age. CONCLUSION: Moderate renal impairment seems to be prevalent in the general population, with an apparent excess in females which is not explained by conventional cardiovascular risk factors. The unexpected finding questions the validity of the prediction equations, in particular in females.
Keywords
Aged Blood Pressure Cardiovascular Diseases/diagnosis/*epidemiology Creatinine/blood Cross-Sectional Studies Female Glomerular Filtration Rate Humans Kidney Failure/*epidemiology Male Middle Aged Prevalence Risk Factors Survival Rate Switzerland/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 10:50
Last modification date
25/09/2019 7:10
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