Cancer Metastasis: A Reappraisal of Its Underlying Mechanisms and Their Relevance to Treatment.

Details

Serval ID
serval:BIB_9CAC46436D31
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Cancer Metastasis: A Reappraisal of Its Underlying Mechanisms and Their Relevance to Treatment.
Journal
Annual review of pathology
Author(s)
Riggi N., Aguet M., Stamenkovic I.
ISSN
1553-4014 (Electronic)
ISSN-L
1553-4006
Publication state
Published
Issued date
24/01/2018
Peer-reviewed
Oui
Volume
13
Pages
117-140
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Metastases are responsible for the vast majority of cancer-related deaths, but, despite intense efforts to understand their underlying mechanisms with the goal of uncovering effective therapeutic targets, treatment of metastatic cancer has progressed minimally. In this review, we examine the biological programs currently proposed to be key drivers of metastasis. On the basis of evidence from a growing body of research, we discuss to what extent the cellular and molecular mechanisms that are suggested to underlie cancer cell dissemination are specific to the metastatic process, as opposed to representing natural primary tumor progression. Our review highlights the contrast between the abundance of insight gained into the events that constitute the metastatic cascade and the paucity of therapeutic options.
Keywords
Humans, Neoplasm Invasiveness/pathology, Neoplasm Metastasis/pathology, Neoplasms/pathology, Neoplastic Stem Cells/pathology, CTC, colonization, dormancy, mechanisms, metastasis, stroma
Pubmed
Web of science
Create date
31/10/2017 9:43
Last modification date
20/08/2019 15:03
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