Microbial regulation of intestinal motility provides resistance against helminth infection.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_9CA74D43298F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Microbial regulation of intestinal motility provides resistance against helminth infection.
Journal
Mucosal Immunology
Author(s)
Moyat M., Lebon L., Perdijk O., Wickramasinghe L.C., Zaiss M.M., Mosconi I., Volpe B., Guenat N., Shah K., Coakley G., Bouchery T., Harris N.L.
ISSN
1935-3456 (Electronic)
ISSN-L
1933-0219
Publication state
Published
Issued date
06/2022
Peer-reviewed
Oui
Volume
15
Number
6
Pages
1283-1295
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Soil-transmitted helminths cause widespread disease, infecting ~1.5 billion people living within poverty-stricken regions of tropical and subtropical countries. As adult worms inhabit the intestine alongside bacterial communities, we determined whether the bacterial microbiota impacted on host resistance against intestinal helminth infection. We infected germ-free, antibiotic-treated and specific pathogen-free mice, with the intestinal helminth Heligmosomoides polygyrus bakeri. Mice harboured increased parasite numbers in the absence of a bacterial microbiota, despite mounting a robust helminth-induced type 2 immune response. Alterations to parasite behaviour could already be observed at early time points following infection, including more proximal distribution of infective larvae along the intestinal tract and increased migration in a Baermann assay. Mice lacking a complex bacterial microbiota exhibited reduced levels of intestinal acetylcholine, a major excitatory intestinal neurotransmitter that promotes intestinal transit by activating muscarinic receptors. Both intestinal motility and host resistance against larval infection were restored by treatment with the muscarinic agonist bethanechol. These data provide evidence that a complex bacterial microbiota provides the host with resistance against intestinal helminths via its ability to regulate intestinal motility.
Keywords
Mice, Animals, Nematospiroides dubius, Intestinal Diseases, Parasitic, Helminthiasis, Gastrointestinal Motility, Strongylida Infections
Pubmed
Web of science
Open Access
Yes
Create date
05/04/2023 9:25
Last modification date
31/01/2024 12:35
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