Recent advances in understanding the genetics of sleep.

Details

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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_9C9A5EBC7283
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Recent advances in understanding the genetics of sleep.
Journal
F1000Research
Author(s)
Jan M., O'Hara B.F., Franken P.
ISSN
2046-1402 (Electronic)
ISSN-L
2046-1402
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
9
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Sleep is a ubiquitous and complex behavior in both its manifestation and regulation. Despite its essential role in maintaining optimal performance, health, and well-being, the genetic mechanisms underlying sleep remain poorly understood. Here, we review the forward genetic approaches undertaken in the last four years to elucidate the genes and gene pathways affecting sleep and its regulation. Despite an increasing number of studies and mining large databases, a coherent picture on "sleep" genes has yet to emerge. We highlight the results achieved by using unbiased genetic screens mainly in humans, mice, and fruit flies with an emphasis on normal sleep and make reference to lessons learned from the circadian field.
Keywords
Forward genetics, GRP, GWAS, Genetic Screen, Genetics, Sleep, Sleep Regulation
Pubmed
Open Access
Yes
Funding(s)
University of Lausanne
Swiss National Science Foundation / Projects / 31003A_146694
Swiss National Science Foundation / Projects / 31003A_173182
Swiss National Science Foundation / Programmes / CRSII3_13620
Create date
25/04/2020 20:30
Last modification date
20/01/2021 6:26
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