A Cellular Perspective on Brain Energy Metabolism and Functional Imaging.

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State: Public
Version: author
Serval ID
serval:BIB_9C72046E95F9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A Cellular Perspective on Brain Energy Metabolism and Functional Imaging.
Journal
Neuron
Author(s)
Magistretti P.J., Allaman I.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
86
Number
4
Pages
883-901
Language
english
Notes
Publication types: <Publication Status: ppublish
Abstract
The energy demands of the brain are high: they account for at least 20% of the body's energy consumption. Evolutionary studies indicate that the emergence of higher cognitive functions in humans is associated with an increased glucose utilization and expression of energy metabolism genes. Functional brain imaging techniques such as fMRI and PET, which are widely used in human neuroscience studies, detect signals that monitor energy delivery and use in register with neuronal activity. Recent technological advances in metabolic studies with cellular resolution have afforded decisive insights into the understanding of the cellular and molecular bases of the coupling between neuronal activity and energy metabolism and point at a key role of neuron-astrocyte metabolic interactions. This article reviews some of the most salient features emerging from recent studies and aims at providing an integration of brain energy metabolism across resolution scales.
Pubmed
Web of science
Open Access
Yes
Create date
26/05/2015 7:57
Last modification date
20/08/2019 15:03
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