Diffusion tensor imaging shows structural remodeling of stroke mirror region: results from a pilot study.

Details

Serval ID
serval:BIB_9C6BAD118BF9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diffusion tensor imaging shows structural remodeling of stroke mirror region: results from a pilot study.
Journal
European Neurology
Author(s)
Granziera C., Ay H., Koniak S.P., Krueger G., Sorensen A.G.
ISSN
1421-9913 (Electronic)
ISSN-L
0014-3022
Publication state
Published
Issued date
2012
Volume
67
Number
6
Pages
370-376
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Background: The role of the non-injured hemisphere in stroke recovery is poorly understood. In this pilot study, we sought to explore the presence of structural changes detectable by diffusion tensor imaging (DTI) in the contralesional hemispheres of patients who recovered well from ischemic stroke. Methods: We analyzed serial DTI data from 16 stroke patients who had moderate initial neurological deficits (NIHSS scores 3-12) and good functional outcome at 3-6 months (NIHSS score 0 or modified Rankin Score ≤1). We segmented the brain tissue in gray and white matter (GM and WM) and measured the apparent diffusion coefficient (ADC) and fractional anisotropy in the infarct, in the contralesional infarct mirror region as well as in concentrically expanding regions around them. Results: We found that GM and WM ADC significantly increased in the infarct region (p < 0.01) from acute to chronic time points, whereas in the infarct mirror region, GM and WM ADC increased (p < 0.01) and WM fractional anisotropy decreased (p < 0.05). No significant changes were detected in other regions. Conclusion: DTI-based metrics are sensitive to regional structural changes in the contralesional hemisphere during stroke recovery. Prospective studies in larger cohorts with varying levels of recovery are needed to confirm our findings.
Pubmed
Web of science
Create date
29/07/2012 14:40
Last modification date
20/08/2019 15:03
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