An alternative to left ventricular volume reduction

Details

Serval ID
serval:BIB_9C59CFE2BB3B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
An alternative to left ventricular volume reduction
Journal
Journal of Heart and Lung Transplantation
Author(s)
Mueller  X. M., Tevaearai  H., Boone  Y., Augstburger  M., von Segesser  L. K.
ISSN
1053-2498
Publication state
Published
Issued date
07/2002
Peer-reviewed
Oui
Volume
21
Number
7
Pages
791-6
Notes
Journal Article --- Old month value: Jul
Abstract
BACKGROUND: Left ventricular (LV) remodeling leading to ventricular dilatation is ultimately a maladaptative process according to the law of Laplace. To counteract the wall stress increase, a new concept of reducing the LV cavity radius by changing the LV globular shape to a bilobular one through the insertion of transventricular splints has emerged. This procedure is tested in a model of congestive heart failure. METHODS: A bovine model was used (n = 9). Following splint insertion through a sternotomy, boluses of 2 liters of crystalloid were injected. After every bolus, hemodynamic measurements were performed without and with the splints tightened to a 10% and 20% stress level reduction, respectively. Comparisons between the 3 measurements were performed with analysis of variance test (p < 0.05). RESULTS: Splint tightening significantly reduced right and left heart pressures for central venous pressure (CVP) >10 mm Hg (CVP: 14.7 +/- 5.2, 12.1 +/- 5, 10.6 +/- 4.7 mm Hg, p < 0.001 for baseline, 10% and 20% stress level reduction, respectively; mean pulmonary artery pressure: 33.5 +/- 4.7, 31 +/- 4.4, 29.4 +/- 5.1 mm Hg, p < 0.001; pulmonary capillary wedge pressure: 20.5 +/- 2.8, 18.9 +/- 3.3, 17.5 +/- 3.1 mm Hg, p < 0.001). The same holds true for cardiac output (6.5 +/- 1.6, 6.7 +/- 1.4, 6.8 +/- 1.7 liter/minute, p < 0.001), whereas heart rate and mean arterial pressure were not affected. The systemic and pulmonary resistances did not vary significantly throughout the procedure. Importantly, none of the hemodynamic parameters worsened at any stage with the splints. CONCLUSIONS: In this model, hemodynamic parameters are improved with the splints for higher values of CVP, supporting the concept of reshaping the remodeled LV. This technique has the potential to improve patients with congestive heart failure.
Keywords
Animals Cattle Disease Models, Animal Heart Failure/physiopathology/*therapy Heart Ventricles Hemodynamics *Prostheses and Implants *Splints
Pubmed
Web of science
Create date
14/02/2008 14:16
Last modification date
20/08/2019 15:03
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