Combination of dynamic and integral methods for generating reproducible functional CBF images.

Details

Serval ID
serval:BIB_9C530AD81B4A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Combination of dynamic and integral methods for generating reproducible functional CBF images.
Journal
Journal of Cerebral Blood Flow and Metabolism
Author(s)
Lammertsma A.A., Cunningham V.J., Deiber M.P., Heather J.D., Bloomfield P.M., Nutt J., Frackowiak R.S., Jones T.
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Publication state
Published
Issued date
1990
Volume
10
Number
5
Pages
675-686
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
A new method to measure regional CBF is presented, applying both dynamic and integral analyses to a dynamic sequence of positron emission tomographic scans collected during and following the administration of H2(15)O (inhalation of C15O2). The dynamic analysis is used to correct continuously monitored arterial whole-blood activity for delay and dispersion relative to tissue scans. An integral analysis including corrections for this delay and dispersion is then used to calculate CBF on a pixel-by-pixel basis. Normal values and reproducibility over a 2-h period are presented, together with the results of validation and simulation studies. The results indicate that the single-tissue compartment model adequately describes the distribution of H2(15)O in the brain, without recourse to postulating a nonexchanging water pool.
Keywords
Carbon Radioisotopes/diagnostic use, Cerebrovascular Circulation, Humans, Models, Biological, Models, Statistical, Oxygen Radioisotopes/diagnostic use, Reference Values, Reproducibility of Results, Tomography, Emission-Computed/methods
Pubmed
Web of science
Open Access
Yes
Create date
06/10/2011 20:06
Last modification date
20/08/2019 15:03
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