Maintenance of remission in Crohn's disease.

Details

Serval ID
serval:BIB_9C47CD646055
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Maintenance of remission in Crohn's disease.
Journal
Digestion
Author(s)
Gonvers J.J., Juillerat P., Mottet C., Felley C., Burnand B., Vader J.P., Michetti P., Froehlich F.
ISSN
0012-2823
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
71
Number
1
Pages
41-8
Language
english
Notes
Publication types: Journal Article ; Review - Publication Status: ppublish
Abstract
When remission of Crohn's disease is achieved, the next goal is to maintain long-term remission. Aminosalicylates may be recommended for maintenance remission, even though the results are less consistent than those observed in ulcerative colitis. The benefit is mainly observed in the post-surgical setting and in patients with ileitis, and with a prolonged disease duration. Corticosteroids are not effective in maintaining remission and should not be used for this indication. Azathioprine and 6-mercaptopurine are effective in maintaining remission. Maintenance benefits remain significant for patients who continued with the therapy for up to 5 years. Methotrexate has also been found to be effective in maintaining remission in Crohn's disease in patients who have responded acutely to methotrexate. Cyclosporine has not been found to be an effective maintenance agent. Mycophenolate mofetil could be considered a therapy in patients who are either allergic to azathioprine or in whom azathioprine failed to induce remission. The use of infliximab may change the future approach to maintenance therapy for Crohn's disease. Patients who responded clinically to infliximab have maintained their clinical response when receiving repeat infusions at 8-week intervals. In patients refractory to other therapies, infliximab may be effective in maintaining remission.
Keywords
Anti-Inflammatory Agents, Non-Steroidal, Crohn Disease, Drug Therapy, Combination, Gastrointestinal Agents, Humans, Immunosuppressive Agents, Remission Induction, Treatment Outcome
Pubmed
Web of science
Create date
25/01/2008 15:58
Last modification date
20/08/2019 15:03
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