Tolylfluanid permeates human skin slowly and as dimethylamino sulfotoluidid (DMST).

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State: Public
Version: Author's accepted manuscript
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Serval ID
serval:BIB_9C289BB3B06E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tolylfluanid permeates human skin slowly and as dimethylamino sulfotoluidid (DMST).
Journal
Toxicology letters
Author(s)
Berthet A., Hechon J., Hopf N.B.
ISSN
1879-3169 (Electronic)
ISSN-L
0378-4274
Publication state
Published
Issued date
15/05/2020
Peer-reviewed
Oui
Volume
324
Pages
38-45
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Tolylfluanid (TF) is a sensitizing biocide used in antifouling products and wood preservatives. Paint application is associated with skin exposure; however, the importance of this exposure route is uncertain as TF skin permeation rates are lacking in the peer-reviewed scientific literature. TF is a lipophilic powder that hydrolyses rapidly in contact with water to dimethylamino sulfotoluidid (DMST). DMST is also a TF metabolite. We characterized TF and DMST skin permeation using an ex vivo flow-through diffusion system with viable and frozen human skin. TF permeated as DMST with a low permeation rate (0.18 ± 0.05 μg/cm <sup>2</sup> /h) and a moderate time lag (7.1 ± 1.4 h) in viable human skin. Applying DMST gave a 3.5-fold lower permeation rate (0.05 ± 0.01 μg/cm <sup>2</sup> /h) compared to TF under a similar experimental setting. We simulated paint activities in an exposure chamber to understand a possible skin exposure from airborne TF concentrations. Although, paint can deposit onto the skin during work activities, TF permeation when paint was applied to human skin ex vivo was very low (as TF: 0.004 ± 0.005 μg/cm <sup>2</sup> /h, and as DMST: 0.02 ± 0.001 μg/cm <sup>2</sup> /h). Our results show that TF can permeate skin, and consequently, can contribute to sensitization, which support previous reports on sensitization in TF exposed workers.
Keywords
Air Pollutants/analysis, Humans, Hydrolysis, Occupational Exposure, Paint, Permeability, Skin/metabolism, Solubility, Sulfonamides/analysis, Sulfonamides/chemistry, Sulfonamides/pharmacokinetics, Toluidines/analysis, Toluidines/chemistry, Toluidines/pharmacokinetics, Biocide, Dermal permeation, Dimethylamino sulfotoluidid (DMST), Human skin, Tolylfluanid
Pubmed
Web of science
Funding(s)
Other / Swiss Federal Office of Public Health (FOPH)
Create date
20/02/2020 12:40
Last modification date
11/07/2020 5:18
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