Genetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese Adults.

Details

Serval ID
serval:BIB_9C1C3C02FA43
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese Adults.
Journal
Diabetes
Author(s)
Gan W., Bragg F., Walters R.G., Millwood I.Y., Lin K., Chen Y., Guo Y., Vaucher J., Bian Z., Bennett D., Lv J., Yu C., Mahajan A., Clarke R.J., Li L., Holmes M.V., McCarthy M.I., Chen Z.
Working group(s)
China Kadoorie Biobank Collaborative Group
Contributor(s)
Chen J., Chen Z., Clarke R., Collins R., Guo Y., Li L., Lv J., Peto R., Walters R., Avery D., Bennett D., Boxall R., Bragg F., Chang Y., Chen Y., Du H., Gilbert S., Hacker A., Holmes M., Iona A., Kartsonaki C., Kerosi R., Kurmi O., Lewington S., Lancaster G., Lin K., McDonnell J., Millwood I., Nie Q., Radhakrishnan J., Ryder P., Sansome S., Schmidt D., Sherliker P., Sohoni R., Stevens B., Turnbull I., Wang J., Wang L., Wright N., Yang L., Yang X., Bian Z., Chen G., Han X., Hou C., Pei P., Qu S., Tan Y., Yu C., Pang Z., Gao R., Wang S., Liu Y., Du R., Zang Y., Cheng L., Tian X., Zhang H., Lv S., Wang J., Hou W., Yin J., Jiang G., Zhou X., Yang L., He H., Yu B., Li Y., Mu H., Xu Q., Dou M., Ren J., Wang S., Hu X., Wang H., Chen J., Fu Y., Fu Z., Wang X., Weng M., Zheng X., Li Y., Li H., Wang Y., Wu M., Zhou J., Tao R., Yang J., Ni C., Zhang J., Hu Y., Lu Y., Ma L., Tang A., Zhang S., Jin J., Liu J., Tang Z., Chen N., Huang Y., Li M., Meng J., Pan R., Jiang Q., Zhang W., Liu Y., Wei L., Zhou L., Chen N., Guan H., Wu X., Zhang N., Chen X., Tang X., Luo G., Li J., Zhong X., Liu J., Sun Q., Ge P., Ren X., Dong C., Zhang H., Mao E., Wang X., Wang T., Zhang X., Zhang D., Zhou G., Feng S., Chang L., Fan L., Gao Y., He T., Sun H., He P., Hu C., Lv Q., Zhang X., Yu M., Hu R., Wang H., Qian Y., Wang C., Xie K., Chen L., Zhang Y., Pan D., Huang Y., Chen B., Yin L., Jin D., Liu H., Fu Z., Xu Q., Xu X., Zhang H., Xiong Y., Long H., Li X., Zhang L., Qiu Z.
ISSN
1939-327X (Electronic)
ISSN-L
0012-1797
Publication state
Published
Issued date
11/2019
Peer-reviewed
Oui
Volume
68
Number
11
Pages
2155-2164
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
In observational studies, type 2 diabetes is associated with two- to fourfold higher risk of cardiovascular diseases (CVD). Using data from the China Kadoorie Biobank (CKB), we examined associations of genetically predicted type 2 diabetes with CVD among ∼160,000 participants to assess whether these relationships are causal. A type 2 diabetes genetic risk score (comprising 48 established risk variants) was associated with the presence of carotid plaque (odds ratio 1.17 [95% CI 1.05, 1.29] per 1 unit higher log-odds of type 2 diabetes; n = 6,819) and elevated risk of ischemic stroke (IS) (1.08 [1.02, 1.14]; n = 17,097), nonlacunar IS (1.09 [1.03, 1.16]; n = 13,924), and major coronary event (1.12 [1.02, 1.23]; n = 5,081). There was no significant association with lacunar IS (1.03 [0.91, 1.16], n = 3,173) or intracerebral hemorrhage (ICH) (1.01 [0.94, 1.10], n = 6,973), although effect estimates were imprecise. These associations were consistent with observational associations of type 2 diabetes with CVD in CKB (P for heterogeneity >0.3) and with the associations of type 2 diabetes with IS, ICH, and coronary heart disease in two-sample Mendelian randomization analyses based on summary statistics from European population genome-wide association studies (P for heterogeneity >0.2). In conclusion, among Chinese adults, genetic predisposition to type 2 diabetes was associated with atherosclerotic CVD, consistent with a causal association.
Keywords
Adult, Atherosclerosis/epidemiology, Atherosclerosis/genetics, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/genetics, China/epidemiology, Diabetes Mellitus, Type 2/epidemiology, Diabetes Mellitus, Type 2/genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Incidence, Male, Middle Aged, Polymorphism, Single Nucleotide, Prevalence, Risk
Pubmed
Web of science
Create date
16/08/2019 20:01
Last modification date
04/04/2020 5:17
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