Auger radiation targeted into DNA: a therapy perspective

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Serval ID
serval:BIB_9C0B49B93F9E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Auger radiation targeted into DNA: a therapy perspective
Journal
European Journal of Nuclear Medicine and Molecular Imaging
Author(s)
Buchegger  F., Perillo-Adamer  F., Dupertuis  Y. M., Bischof Delaloye A.
ISSN
1619-7070 (Print)
Publication state
Published
Issued date
11/2006
Volume
33
Number
11
Pages
1352-63
Notes
Journal Article Research Support, Non-U.S. Gov't Review --- Old month value: Nov
Abstract
BACKGROUND: Auger electron emitters that can be targeted into DNA of tumour cells represent an attractive systemic radiation therapy goal. In the situation of DNA-associated decay, the high linear energy transfer (LET) of Auger electrons gives a high relative biological efficacy similar to that of alpha particles. In contrast to alpha radiation, however, Auger radiation is of low toxicity when decaying outside the cell nucleus, as in cytoplasm or outside cells during blood transport. The challenge for such therapies is the requirement to target a high percentage of all cancer cells. An overview of Auger radiation therapy approaches of the past decade shows several research directions and various targeting vehicles. The latter include hormones, peptides, halogenated nucleotides, oligonucleotides and internalising antibodies. DISCUSSION: Here, we will discuss the basic principles of Auger electron therapy as compared with vector-guided alpha and beta radiation. We also review some radioprotection issues and briefly present the main advantages and disadvantages of the different targeting modalities that are under investigation.
Keywords
*DNA Damage DNA, Neoplasm/*radiation effects Electrons/*therapeutic use Humans Neoplasms/*genetics/*radiotherapy Radioisotopes/*therapeutic use Radiopharmaceuticals/therapeutic use
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 11:27
Last modification date
01/10/2019 6:18
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