Exercise training in chronic hypoxia has no effect on ventilatory muscle function in humans.

Details

Serval ID
serval:BIB_9BDE0A648522
Type
Article: article from journal or magazin.
Collection
Publications
Title
Exercise training in chronic hypoxia has no effect on ventilatory muscle function in humans.
Journal
Respiration Physiology
Author(s)
Thomas R.G., LaStayo P.C., Hoppeler H., Favier R., Ferretti G., Kayser B., Desplanches D., Spielvogel H., Lindstedt S.L.
ISSN
0034-5687 (Print)
ISSN-L
0034-5687
Publication state
Published
Issued date
1998
Volume
112
Number
2
Pages
195-202
Language
english
Abstract
At the highest altitude, aerobic work is limited by environmental oxygen availability. We therefore reasoned that the hyperpnea associated with endurance training at altitude should provide a strong stimulus for adaptation of the ventilatory muscles. We measured peak inspiratory muscle pressure-flow characteristics (inspiring through graded resistors) and maximum sustainable ventilation capacity in ten permanent residents of La Paz, Bolivia (3600 m) prior to and immediately following 6 weeks of incremental endurance training. Additionally, eight local residents did no training and functioned as controls for the capacity test. While V(O2)max measured in hypoxia increased by 19% (Favier et al., 1995b. J. Appl Physiol. 78, 2286-2293.), none of the tested ventilatory variables showed significant changes. The values for the group mean slopes of maximum inspiratory pressure-flow pairs (- 10.5 vs. - 9.8 cm H2O x sec x L(-1), P=0.301; before versus after training, respectively), maximum inspiratory pressure (112.1+/-8.9 vs. 106.9+/-8.6 cmH2O, P=0.163), peak inspiratory flow (9.8+/-0.41 vs. 10.2+/-0.55 L x sec(-1) P=0.172) and the maximum volitional volume in 12 sec (43.9+/-2.4 vs. 45.6+/-2.4 L in 12 sec, P=0.133) were unchanged with exercise training. Likewise, maximal sustainable minute volume was not different between post-training and control subjects (177.4+/-7.9 vs. 165.4+/-8.4 L x min(-1), P=0.141). These data support the concept that endurance training fails to elicit functional adaptations in ventilatory muscles in humans, even when exercise is done in hypoxia.
Keywords
Acclimatization, Adaptation, Physiological, Adult, Altitude, Anoxia/physiopathology, Anoxia/therapy, Chronic Disease, Exercise Test, Exercise Therapy, Humans, Lung Volume Measurements, Male, Physical Endurance/physiology, Respiratory Muscles/physiopathology
Pubmed
Web of science
Create date
25/09/2013 12:11
Last modification date
20/08/2019 15:02
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