Electroencephalography-based power spectra allow coma outcome prediction within 24 h of cardiac arrest.

Details

Serval ID
serval:BIB_9BC456CC78CE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Electroencephalography-based power spectra allow coma outcome prediction within 24 h of cardiac arrest.
Journal
Resuscitation
Author(s)
Kustermann T., Nguepnjo Nguissi N.A., Pfeiffer C., Haenggi M., Kurmann R., Zubler F., Oddo M., Rossetti A.O., De Lucia M.
ISSN
1873-1570 (Electronic)
ISSN-L
0300-9572
Publication state
Published
Issued date
09/2019
Peer-reviewed
Oui
Volume
142
Pages
162-167
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Outcome prediction in comatose patients following cardiac arrest remains challenging. Here, we assess the predictive performance of electroencephalography-based power spectra within 24 h from coma onset.
We acquired electroencephalography (EEG) from comatose patients (n = 138) on the first day of coma in four hospital sites in Switzerland. Outcome was categorised as favourable or unfavourable based on the best state within three months. Data were split in training and test sets. We evaluated the predictive performance of EEG power spectra for long term outcome and its added value to standard clinical tests.
Out of 138 patients, 80 had a favourable outcome. Power spectra comparison between favourable and unfavourable outcome in the training set yielded significant differences at 5.2-13.2 Hz and above 21 Hz. Outcome prediction based on power at 5.2-13.2 Hz was accurate in training and test sets. Overall, power spectra predicted patients' outcome with maximum specificity and positive predictive value: 1.00 (95% with CI: 0.94-1.00 and 0.89-1.00, respectively). The combination of power spectra and reactivity yielded better accuracy and sensitivity (0.81, 95% CI: 0.71-0.89) than prediction based on power spectra alone.
On the first day of coma following cardiac arrest, low power spectra values around 10 Hz, typically linked to impaired cortico-thalamic structural connections, are highly specific of unfavourable outcome. Peaks in this frequency range can predict long-term outcome.
Keywords
Coma, Consciousness, EEG
Pubmed
Web of science
Open Access
Yes
Create date
14/06/2019 16:02
Last modification date
10/10/2019 5:10
Usage data