Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.

Details

Serval ID
serval:BIB_9B80282AA89D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.
Journal
Frontiers in psychiatry
Author(s)
Tordjman S., Somogyi E., Coulon N., Kermarrec S., Cohen D., Bronsard G., Bonnot O., Weismann-Arcache C., Botbol M., Lauth B., Ginchat V., Roubertoux P., Barburoth M., Kovess V., Geoffray M.M., Xavier J.
ISSN
1664-0640 (Print)
ISSN-L
1664-0640
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
5
Pages
53
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Several studies support currently the hypothesis that autism etiology is based on a polygenic and epistatic model. However, despite advances in epidemiological, molecular and clinical genetics, the genetic risk factors remain difficult to identify, with the exception of a few chromosomal disorders and several single gene disorders associated with an increased risk for autism. Furthermore, several studies suggest a role of environmental factors in autism spectrum disorders (ASD). First, arguments for a genetic contribution to autism, based on updated family and twin studies, are examined. Second, a review of possible prenatal, perinatal, and postnatal environmental risk factors for ASD are presented. Then, the hypotheses are discussed concerning the underlying mechanisms related to a role of environmental factors in the development of ASD in association with genetic factors. In particular, epigenetics as a candidate biological mechanism for gene × environment interactions is considered and the possible role of epigenetic mechanisms reported in genetic disorders associated with ASD is discussed. Furthermore, the example of in utero exposure to valproate provides a good illustration of epigenetic mechanisms involved in ASD and innovative therapeutic strategies. Epigenetic remodeling by environmental factors opens new perspectives for a better understanding, prevention, and early therapeutic intervention of ASD.
Keywords
autistic spectrum disorders, environment, epigenetics, gene × environment interactions, multidisciplinary, multifactorial
Pubmed
Web of science
Open Access
Yes
Create date
15/08/2019 9:18
Last modification date
03/09/2019 5:26
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