Population-specific FST values for forensic STR markers: A worldwide survey.

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State: Public
Version: Final published version
Serval ID
serval:BIB_9B3839201122
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Population-specific FST values for forensic STR markers: A worldwide survey.
Journal
Forensic Science International. Genetics
Author(s)
Buckleton J., Curran J., Goudet J., Taylor D., Thiery A., Weir B.S.
ISSN
1878-0326 (Electronic)
ISSN-L
1872-4973
Publication state
Published
Issued date
2016
Volume
23
Pages
91-100
Language
english
Abstract
The interpretation of matching between DNA profiles of a person of interest and an item of evidence is undertaken using population genetic models to predict the probability of matching by chance. Calculation of matching probabilities is straightforward if allelic probabilities are known, or can be estimated, in the relevant population. It is more often the case, however, that the relevant population has not been sampled and allele frequencies are available only from a broader collection of populations as might be represented in a national or regional database. Variation of allele probabilities among the relevant populations is quantified by the population structure quantity FST and this quantity affects matching proportions. Matching within a population can be interpreted only with respect to matching between populations and we show here that FST, can be estimated from sample allelic matching proportions within and between populations. We report such estimates from data we extracted from 250 papers in the forensic literature, representing STR profiles at up to 24 loci from nearly 500,000 people in 446 different populations. The results suggest that theta values in current forensic use do not have the buffer of conservatism often thought.

Keywords
Forensic DNA, STR marker, Theta, Coancestry
Pubmed
Web of science
Create date
12/01/2017 12:46
Last modification date
20/08/2019 15:02
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