Effective plots to assess bias and precision in method comparison studies.
Details
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_9B1DB0248B24
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effective plots to assess bias and precision in method comparison studies.
Journal
Statistical methods in medical research
ISSN
1477-0334 (Electronic)
ISSN-L
0962-2802
Publication state
Published
Issued date
06/2018
Peer-reviewed
Oui
Volume
27
Number
6
Pages
1650-1660
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Bland and Altman's limits of agreement have traditionally been used in clinical research to assess the agreement between different methods of measurement for quantitative variables. However, when the variances of the measurement errors of the two methods are different, Bland and Altman's plot may be misleading; there are settings where the regression line shows an upward or a downward trend but there is no bias or a zero slope and there is a bias. Therefore, the goal of this paper is to clearly illustrate why and when does a bias arise, particularly when heteroscedastic measurement errors are expected, and propose two new plots, the "bias plot" and the "precision plot," to help the investigator visually and clinically appraise the performance of the new method. These plots do not have the above-mentioned defect and still are easy to interpret, in the spirit of Bland and Altman's limits of agreement. To achieve this goal, we rely on the modeling framework recently developed by Nawarathna and Choudhary, which allows the measurement errors to be heteroscedastic and depend on the underlying latent trait. Their estimation procedure, however, is complex and rather daunting to implement. We have, therefore, developed a new estimation procedure, which is much simpler to implement and, yet, performs very well, as illustrated by our simulations. The methodology requires several measurements with the reference standard and possibly only one with the new method for each individual.
Keywords
Bland–Altman’s plot, Limits of agreement, best linear unbiased prediction, differential bias, empirical Bayes, measurement, method comparison, proportional bias
Pubmed
Web of science
Create date
11/06/2018 17:34
Last modification date
20/08/2019 16:02