The daily energy expenditure in stable chronic obstructive pulmonary disease.

Details

Serval ID
serval:BIB_9B1894CD571D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The daily energy expenditure in stable chronic obstructive pulmonary disease.
Journal
American Journal of Respiratory and Critical Care Medicine
Author(s)
Hugli O., Schutz Y., Fitting J.W.
ISSN
1073-449X (Print)
ISSN-L
1073-449X
Publication state
Published
Issued date
1996
Peer-reviewed
Oui
Volume
153
Number
1
Pages
294-300
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Resting energy expenditure is frequently increased in chronic obstructive pulmonary disease (COPD), but it is unknown if this hypermetabolism holds true over 24 h. The aim of this study was to measure the actual 24-h energy expenditure (24-h EE) in patients with stable COPD. Energy expenditure was measured by indirect calorimetry, using a metabolic chamber for 24-h EE and a canopy for basal metabolic rate (BMR). Physical activity was detected in the chamber by a radar system, and its duration was quantified. Two groups matched for age and height were studied: 16 male ambulatory patients with stable COPD and 12 male normal subjects. Body weight was 92 +/- 12% of ideal body weight in the group with COPD and 108 +/- 11% in the control group (p = 0.01). BMR was 120 +/- 7% of predicted in the group with COPD and 108 +/- 12% in the control group (p < 0.01). However, 24-h EE was similar in the two groups, amounting to 1,935 +/- 259 kcal in patients with COPD and 2,046 +/- 253 kcal in the control group (NS). This corresponded to 145% and 137% of predicted BMR, and to 121% and 126% of measured BMR in patients with COPD and the control group, respectively (NS). Patients were allowed to pursue their usual treatment within the chamber, and a positive correlation existed between 24-h EE and the daily dose of inhaled beta 2-agonists (p < 0.03). During daytime, physical activity was lower in patients with COPD. This study shows that patients with stable COPD are characterized by a normal daily energy expenditure in controlled conditions in spite of an increased basal metabolic rate. They appear to save energy by reducing their spontaneous level of physical activity.
Keywords
Administration, Inhalation, Adrenergic beta-Agonists/administration & dosage, Aged, Albuterol/administration & dosage, Basal Metabolism, Bronchodilator Agents/administration & dosage, Catecholamines/urine, Diet, Energy Metabolism, Humans, Lung Diseases, Obstructive/metabolism, Lung Diseases, Obstructive/physiopathology, Male, Middle Aged, Physical Exertion, Regression Analysis, Respiratory Function Tests, Time Factors
Pubmed
Web of science
Create date
29/01/2008 8:42
Last modification date
20/08/2019 15:02
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