Exploring the clinical relevance of a dichotomy between affective and non-affective psychosis: Results from a first-episode psychosis cohort study.

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Serval ID
serval:BIB_9AC54B4069AC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Exploring the clinical relevance of a dichotomy between affective and non-affective psychosis: Results from a first-episode psychosis cohort study.
Journal
Early intervention in psychiatry
Author(s)
Ramain J., Conus P., Golay P.
ISSN
1751-7893 (Electronic)
ISSN-L
1751-7885
Publication state
Published
Issued date
02/2022
Peer-reviewed
Oui
Volume
16
Number
2
Pages
168-177
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Defining diagnosis is complex in early psychosis, which may delay the introduction of an appropriate treatment. The dichotomy of affective and non-affective psychosis is used in clinical setting but remains questioned on a scientific basis. In this study, we explore the clinical relevance of this dichotomy on the basis of clinical variables in a sample of first-episode psychosis patients.
We conducted a prospective study in a sample of 330 first-episode psychosis treated at an early intervention program. Affective and non-affective psychosis patients were compared on premorbid history, baseline data, outcomes and course of symptoms over the 3 years of treatment.
Affective psychosis patients (22.42%) were more likely to be female, and had a shorter duration of untreated psychosis. The longitudinal analyses revealed that positive symptoms remained higher over the entire follow-up in the non-affective sub-group. A higher degree of variability of manic symptoms and a significantly better insight after 6 months were observed in the affective sub-group. No difference was observed regarding depressive and negative symptoms. At discharge, only the environmental quality of life and insight recovery were better in affective psychosis.
Our study suggests that despite marginal differences at baseline presentation, these sub-groups differ regarding outcome, which may require differentiation of treatment and supports the utility of this dichotomy.
Keywords
Cohort Studies, Female, Humans, Male, Prospective Studies, Psychotic Disorders/complications, Psychotic Disorders/diagnosis, Psychotic Disorders/psychology, Quality of Life, Time Factors, early medical intervention, mood disorders, patient outcome assessment, psychotic disorders, symptom assessment
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / 51AU40_185897
Swiss National Science Foundation / 320030_122419
Create date
08/03/2021 9:20
Last modification date
09/04/2022 6:33
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