Activity of antifungal combinations against Aspergillus species evaluated by isothermal microcalorimetry.

Details

Serval ID
serval:BIB_9AB53CCAEF25
Type
Article: article from journal or magazin.
Collection
Publications
Title
Activity of antifungal combinations against Aspergillus species evaluated by isothermal microcalorimetry.
Journal
Diagnostic Microbiology and Infectious Disease
Author(s)
Furustrand Tafin U., Orasch C., Trampuz A.
ISSN
1879-0070 (Electronic)
ISSN-L
0732-8893
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
77
Number
1
Pages
31-36
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
We evaluated the activity of antifungals alone or in combination against Aspergillus fumigatus and Aspergillus terreus by real-time measurement of fungal growth-related heat production. Amphotericin B, voriconazole, caspofungin, and anidulafungin were tested alone or in combination. Heat production was measured in Sabouraud dextrose broth containing 10(5)Aspergillus conidia/mL for 48 h at 37 °C. Antifungal activity was evaluated by measuring the heat detection time relative to the growth control. Against A. fumigatus, the voriconazole-echinocandin combination demonstrated longer heat detection time than each antifungal alone. Against A. terreus, the combination amphotericin B-echinocandin prolonged the heat detection time, compared to each antifungal alone. In contrast, the echinocandin-voriconazole combination did not increase the heat detection time, compared to voriconazole alone. None of the antifungal combinations decreased the heat detection time compared to the antifungals alone (e.g. antagonism was not observed). Microcalorimetry has the potential for real-time evaluation of antifungal combinations against Aspergillus spp.
Pubmed
Web of science
Create date
12/09/2013 18:31
Last modification date
03/03/2018 19:52
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