The Enigma of Eosinophil Degranulation.

Details

Serval ID
serval:BIB_9A1E04669CAC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The Enigma of Eosinophil Degranulation.
Journal
International journal of molecular sciences
Author(s)
Fettrelet T., Gigon L., Karaulov A., Yousefi S., Simon H.U.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
30/06/2021
Peer-reviewed
Oui
Volume
22
Number
13
Pages
7091
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Eosinophils are specialized white blood cells, which are involved in the pathology of diverse allergic and nonallergic inflammatory diseases. Eosinophils are traditionally known as cytotoxic effector cells but have been suggested to additionally play a role in immunomodulation and maintenance of homeostasis. The exact role of these granule-containing leukocytes in health and diseases is still a matter of debate. Degranulation is one of the key effector functions of eosinophils in response to diverse stimuli. The different degranulation patterns occurring in eosinophils (piecemeal degranulation, exocytosis and cytolysis) have been extensively studied in the last few years. However, the exact mechanism of the diverse degranulation types remains unknown and is still under investigation. In this review, we focus on recent findings and highlight the diversity of stimulation and methods used to evaluate eosinophil degranulation.
Keywords
Cell Degranulation, Eosinophils/metabolism, Eosinophils/pathology, Extracellular Traps/metabolism, Humans, Hypersensitivity/metabolism, Hypersensitivity/pathology, cytolysis, degranulation, eosinophil extracellular trap, eosinophils, exocytosis, granule proteins, piecemeal degranulation
Pubmed
Web of science
Open Access
Yes
Create date
12/07/2021 11:06
Last modification date
24/07/2021 5:34
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