Active Nano-targeting of Macrophages.

Details

Serval ID
serval:BIB_9A17D79A11D6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Active Nano-targeting of Macrophages.
Journal
Current pharmaceutical design
Author(s)
Gaspar N., Zambito G., Löwik CMWG, Mezzanotte L.
ISSN
1873-4286 (Electronic)
ISSN-L
1381-6128
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
25
Number
17
Pages
1951-1961
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Macrophages play a role in almost every disease such as cancer, infections, injuries, metabolic and inflammatory diseases and are becoming an attractive therapeutic target. However, understanding macrophage diversity, tissue distribution and plasticity will help in defining precise targeting strategies and effective therapies. Active targeting of macrophages using nanoparticles for therapeutic purposes is still at its infancy but holds promises since macrophages have shown high specific uptake of nanoparticles. Here, we highlight recent progress in active nanotechnology-based systems gaining pivotal roles to target diverse macrophage subsets in diseased tissues.
Keywords
Drug Delivery Systems, Humans, Macrophages/drug effects, Nanoparticles, Nanotechnology/trends, active and passive nano-targeting, asthma, cancer, cardiovascular diseases, inflammatory diseases, macrophage depletion, macrophage polarization, macrophage reprogramming, metabolic diseases.
Pubmed
Web of science
Create date
05/03/2020 17:15
Last modification date
23/10/2020 5:23
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