Successful serology-based intervention to increase protection against vaccine-preventable diseases in liver-transplanted children: a 19-yr review of the Swiss national reference center.

Details

Serval ID
serval:BIB_9A052F32132A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Successful serology-based intervention to increase protection against vaccine-preventable diseases in liver-transplanted children: a 19-yr review of the Swiss national reference center.
Journal
Pediatric Transplantation
Author(s)
L'Huillier A.G., Wildhaber B.E., Belli D.C., Diana A., Rodriguez M., Siegrist C.A., Posfay-Barbe K.M.
ISSN
1399-3046 (Electronic)
ISSN-L
1397-3142
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
16
Number
1
Pages
50-57
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
As children referred for OLT in Switzerland were not vaccinated optimally, new guidelines were developed and recommended to base catch-up immunization on serum antibody titers against vaccine-preventable diseases, before and after OLT. We measure the results of this serology-based intervention by comparing vaccine coverage and antibody titers in the pre- (1990-2002, P1) and post-intervention (2003-2008, P2) cohorts in a quality control project. Forty-four P1 and 30 P2 children were evaluated. At pre-OLT visit, D, T, SPn, and MMR serologies were checked more frequently in P2 than P1 (p < 0.05). More P2 children were up-to-date for DTaP and MMR (p < 0.05) or had received ≥1 dose of HBV, HAV, SPn, and VZV vaccines (p < 0.05). One yr post-OLT, DT, SPn, MMR, and VZV serologies were more frequently checked (p < 0.05), and antibody titers were higher for DT and HAV (p < 0.05) in P2. Gender, age, or diagnosis did not explain these differences. Among P2 patients, pre- and post-OLT titers for D, T, Hib, HBV, SPn14, and SPn19 were correlated (p < 0.05 for all). Protection against vaccine-preventable diseases of high-risk children like OLT patients can be significantly improved by serology-based intervention for vaccine-preventable diseases.
Keywords
Child, Child, Preschool, Cohort Studies, Communicable Disease Control, Female, Humans, Immunization Schedule, Infant, Liver Failure/blood, Liver Failure/complications, Liver Transplantation/methods, Male, Quality Control, Registries, Serology/methods, hic" UI="D013557">Switzerland, Treatment Outcome, Vaccination/methods, Vaccines/therapeutic use, Virus Diseases/complications, Virus Diseases/prevention & control
Pubmed
Web of science
Create date
21/02/2015 11:45
Last modification date
03/03/2018 19:51
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